{"id":"W3173570013","doi":"10.1128/jvi.00687-21","title":"Construction of a Noninfectious SARS-CoV-2 Replicon for Antiviral-Drug Testing and Gene Function Studies","year":2021,"lang":"en","type":"article","venue":"Journal of Virology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institute on Deafness and Other Communication Disorders; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Ministry of Agriculture - Saskatchewan","keywords":"Biology; Virology; Replicon; Pandemic; Antiviral drug; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Drug; Betacoronavirus; Gene; Virus; Genetics; Genome; Infectious disease (medical specialty); Pharmacology; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007406824,0.0007031347,0.000598223,0.0005881952,0.0003424371,0.0004014158,0.0006211098,0.0004545431,0.001706753],"category_scores_gemma":[0.0005758006,0.0003556191,0.0004923309,0.0004086659,0.0003512926,0.0004471877,0.0004909561,0.001068009,0.0008938411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003978865,"about_ca_system_score_gemma":0.0004377392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005948449,"about_ca_topic_score_gemma":0.0009892216,"domain_scores_codex":[0.9995338,0.0001377754,0.00005922198,0.00009234174,0.0001139521,0.0000630137],"domain_scores_gemma":[0.99968,0.0001002538,0.00006813298,0.00007357433,0.00003585449,0.00004209646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007663436,0.00006049121,0.0001407072,0.00004206515,0.000006463493,0.00007020664,0.00003128663,0.0001909612,0.997539,0.0003212984,0.00009926723,0.001421736],"study_design_scores_gemma":[0.00005562799,0.000670357,0.001922338,0.00001194017,0.00003543272,0.0002058908,0.0000315438,0.002412062,0.9883106,0.0001474908,0.006173369,0.00002329015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8317367,0.001756489,0.1497018,0.000432083,0.0004199154,0.002159986,0.008023755,0.0009764722,0.004792893],"genre_scores_gemma":[0.802218,0.001251727,0.1696532,0.0001566435,0.00006608594,0.0011993,0.01914489,0.0003291811,0.005980939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001706753,"threshold_uncertainty_score":0.005709648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07731405681268966,"score_gpt":0.3819382510938581,"score_spread":0.3046241942811685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}