{"id":"W3173593446","doi":"10.1101/2021.06.28.450088","title":"A novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"BC Cancer Foundation; Terry Fox Research Institute; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Thioredoxin reductase; Synthetic lethality; Small molecule; Thioredoxin; Glutathione; Cell biology; Cell culture; Cytotoxicity; Reactive oxygen species; Chemistry; Cell signaling; Proteome; Biology; Oxidative stress; Cancer research; Biochemistry; Mutant; Signal transduction; Enzyme; In vitro; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009720518,0.0002468706,0.0002814756,0.0001836647,0.0001131269,0.0001655969,0.000152155,0.0002110985,0.001232727],"category_scores_gemma":[0.00005720155,0.00009192155,0.0002452972,0.0001618713,0.0001462304,0.00008485869,0.0001360357,0.000279026,0.0003463703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002368156,"about_ca_system_score_gemma":0.0001883341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005396499,"about_ca_topic_score_gemma":0.0009030169,"domain_scores_codex":[0.9999424,0.000006751454,0.000004087473,0.0000100982,0.00002602661,0.00001071609],"domain_scores_gemma":[0.9999715,0.000006015921,0.000007555378,0.000003833731,0.000004657109,0.000006476264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005006339,0.00001910914,0.00009937076,0.00002366341,0.000004744232,0.00002784434,0.000003510446,0.0001067113,0.9984004,0.00005669713,0.00006698079,0.001140927],"study_design_scores_gemma":[0.00001313956,0.0001689922,0.000701326,0.00000145986,0.00000522252,0.00006407244,0.000003821759,0.0004831684,0.9972024,0.00001721991,0.001337999,0.00000122514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870222,0.001793706,0.006479901,0.00023749,0.00005881599,0.00008025595,0.001041885,0.0002830325,0.003002765],"genre_scores_gemma":[0.9902835,0.000910068,0.003839672,0.00009889979,0.000009461085,0.0000454571,0.001070416,0.00002958734,0.003712771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001232727,"threshold_uncertainty_score":0.004123867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0163111232263728,"score_gpt":0.2426616345154587,"score_spread":0.2263505112890859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}