{"id":"W3173690562","doi":"10.1096/fasebj.26.1_supplement.666.2","title":"Implication of reduced levels of intracellular cAMP in enhanced expression of Gi proteins and hyperproliferation of vascular smooth muscle cells from spontaneously hypertensive rats: cellular mechanisms","year":2012,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Vascular smooth muscle; Intracellular; Endocrinology; Signal transduction; Internal medicine; Angiotensin II; Cell growth; Phosphorylation; Chemistry; Western blot; Cell biology; Downregulation and upregulation; Biology; Medicine; Biochemistry; Smooth muscle; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001105664,0.0003199958,0.0003307715,0.0003035135,0.0001540113,0.0001642752,0.0001307324,0.0002320983,0.0009224895],"category_scores_gemma":[0.0000758777,0.0001731696,0.0002274741,0.0001120723,0.0002919582,0.0001897268,0.0001910294,0.0006420185,0.0001070639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001714438,"about_ca_system_score_gemma":0.0001230909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008729737,"about_ca_topic_score_gemma":0.001086343,"domain_scores_codex":[0.9999232,0.000011437,0.000006121866,0.00001479586,0.00002030343,0.00002414926],"domain_scores_gemma":[0.9998993,0.000009509342,0.00003117711,0.00001107374,0.00001130482,0.00003752981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001034324,0.00001475645,0.0003273666,0.00003516851,0.000004394704,0.0001278582,0.00001815614,0.000009002491,0.9988508,0.00003401784,0.00001022592,0.0004647213],"study_design_scores_gemma":[0.00004519657,0.000682635,0.1319858,0.00001293731,0.00006450136,0.0009987609,0.0001366789,0.0006876695,0.8641352,0.0001931834,0.001045381,0.00001212041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969655,0.001338958,0.0008432445,0.0001531491,0.00001569155,0.0000114144,0.0001309754,0.00003142804,0.000509684],"genre_scores_gemma":[0.9973813,0.0009629155,0.000701302,0.00005266486,0.00002321298,0.00001893768,0.0001755798,0.000005393009,0.0006787497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009224895,"threshold_uncertainty_score":0.00308609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01096519150124279,"score_gpt":0.2171729988729678,"score_spread":0.206207807371725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}