{"id":"W3173796517","doi":"10.1101/2021.06.29.450454","title":"The P-selectin ligand PSGL-1 (CD162) is efficiently incorporated by primary HIV-1 isolates and can facilitate trans-infection","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University of Toronto","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; University of Ottawa","keywords":"Ectodomain; Infectivity; Biology; Virology; Virus; Transfection; Ligand (biochemistry); Glycoprotein; Receptor; Gp41; Cell biology; Cell culture; Antigen; Immunology; Molecular biology; Genetics; Epitope","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008096656,0.0003078067,0.0001789379,0.0001302681,0.0001275539,0.0003257894,0.0001234864,0.0001494282,0.001677544],"category_scores_gemma":[0.00009633555,0.00007848375,0.0001454422,0.0000919325,0.0001155743,0.0001003325,0.0001979882,0.0004026303,0.0004763817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002170876,"about_ca_system_score_gemma":0.0001350301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005460841,"about_ca_topic_score_gemma":0.0006241166,"domain_scores_codex":[0.9998851,0.00001888594,0.000006837177,0.00001716029,0.00003339728,0.0000386611],"domain_scores_gemma":[0.9999368,0.00001431815,0.00001085127,0.00001115812,0.000007296597,0.00001957981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002195214,0.00001278596,0.00006795707,0.000008545454,0.000001281282,0.0000216156,0.000006502632,0.00001728943,0.9995105,0.00002648575,0.00002233907,0.0002828109],"study_design_scores_gemma":[0.00000480777,0.0001525148,0.002076482,0.000003281792,0.000004438974,0.0001693429,0.00001707908,0.0005288038,0.9957046,0.00002501181,0.001312092,0.000001582128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963248,0.0004858147,0.001751895,0.00002780443,0.00001492871,0.00002041028,0.0002165984,0.00004760464,0.00110999],"genre_scores_gemma":[0.9940116,0.0003341009,0.001500153,0.00002636939,0.000007209706,0.00002342812,0.0005125479,0.00001629782,0.003568322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001677544,"threshold_uncertainty_score":0.005611956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01082221720613886,"score_gpt":0.2063755527208963,"score_spread":0.1955533355147574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}