{"id":"W3173828563","doi":"10.20944/preprints202104.0469.v1","title":"How Do Enveloped Viruses Exploit the Secretory Proprotein Convertases to Regulate Infectivity and Spread?","year":2021,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"H2020 Marie Skłodowska-Curie Actions; Canadian Institutes of Health Research; Horizon 2020 Framework Programme","keywords":"Furin; Proprotein Convertases; Viral envelope; Glycoprotein; Proprotein convertase; Viral entry; Biology; Proteases; Cell biology; Virology; Infectivity; Virus; Viral replication; Biochemistry; LDL receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00101844,0.0004936926,0.0007858725,0.0002514162,0.0002958374,0.0002604577,0.0003129945,0.0004142822,0.001048158],"category_scores_gemma":[0.001297594,0.0003620804,0.000252979,0.0003350236,0.0003283216,0.0001974227,0.003534964,0.001643426,0.0002501165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002577762,"about_ca_system_score_gemma":0.000590773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001976887,"about_ca_topic_score_gemma":0.0002382382,"domain_scores_codex":[0.9967054,0.0004291914,0.0003864644,0.001314608,0.0006346484,0.0005297544],"domain_scores_gemma":[0.9970012,0.0001580284,0.0001748763,0.001770953,0.0004814552,0.0004134515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004704289,0.0005191287,0.7747281,0.001463692,0.0009276122,0.0002335136,0.002434853,0.00005909038,0.2070157,0.0002233763,0.0003671766,0.01155734],"study_design_scores_gemma":[0.0007574824,0.0001479374,0.6147525,0.0005993978,0.0003081649,0.0001331495,0.0006070761,0.0001188616,0.3635071,0.0002273246,0.01828832,0.0005527433],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880992,0.0004412488,0.0004936222,0.005451561,0.0002787523,0.003147798,0.00003800374,0.0001939164,0.001855958],"genre_scores_gemma":[0.9915252,0.0003916902,0.0001810735,0.0006119697,0.0002837557,0.0011088,0.00003696192,0.00007305675,0.005787443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1599756,"threshold_uncertainty_score":0.9998831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1778851878304821,"score_gpt":0.3824384220211121,"score_spread":0.20455323419063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}