{"id":"W3173862775","doi":"10.4049/jimmunol.2100125","title":"Zebrafish Uba1 Degrades IRF3 through K48-Linked Ubiquitination to Inhibit IFN Production","year":2021,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"Youth Innovation Promotion Association; National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"IRF3; Ubiquitin; Proteasome; Cell biology; Interferon regulatory factors; MG132; Transcription factor; Biology; Ubiquitin ligase; Zebrafish; Protein degradation; Proteasome inhibitor; Chemistry; Molecular biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009217396,0.0001960693,0.0004156731,0.0001770624,0.0002869176,0.0000234762,0.0004222746,0.0002509903,0.0006450902],"category_scores_gemma":[0.001171216,0.00013719,0.0001644539,0.0003165364,0.0003012578,0.0002453667,0.0001735551,0.0007664055,0.0004422649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001059121,"about_ca_system_score_gemma":0.0002086951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002749012,"about_ca_topic_score_gemma":0.00003188878,"domain_scores_codex":[0.9973291,0.001348178,0.0006993817,0.0001745044,0.00006802534,0.0003808262],"domain_scores_gemma":[0.9981926,0.0003011696,0.0004350778,0.0003883311,0.0006668054,0.00001600522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001632942,0.0001662893,0.00003398806,0.000007259106,0.0004137175,0.00001757787,0.00267183,0.00001436104,0.9739827,0.001265086,0.01233908,0.007455176],"study_design_scores_gemma":[0.0009413352,0.0009092843,0.005637039,0.0001005007,0.00009645557,0.005408161,0.002835915,2.503555e-7,0.8737659,0.0006015537,0.1095599,0.0001436961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9608683,0.02044788,0.0006141246,0.01345971,0.003394615,0.0001675185,0.000004134384,0.00003198614,0.001011706],"genre_scores_gemma":[0.9886657,0.001934839,0.0002326494,0.00100647,0.0001515417,0.000005400651,0.00001338079,0.00002310357,0.007966887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1002168,"threshold_uncertainty_score":0.7063286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02033108727570068,"score_gpt":0.2662347057559429,"score_spread":0.2459036184802423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}