{"id":"W3174005929","doi":"10.1096/fasebj.2019.33.1_supplement.515.13","title":"Exosome Packaging of the Targeted Antioxidant CAT‐SKL to Protect the Sensory Cells in the Inner Ear","year":2019,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; W. Garfield Weston Foundation","keywords":"Ototoxicity; Oxidative stress; Cochlea; Viability assay; Antioxidant; Microvesicles; Pharmacology; Catalase; Reactive oxygen species; Cisplatin; Cell biology; Medicine; Cell; Chemistry; Biology; Biochemistry; Internal medicine; Chemotherapy; Audiology; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002724384,0.0002436787,0.0001980427,0.0001337992,0.0001299843,0.0003467053,0.0001988438,0.0003762037,0.0005819108],"category_scores_gemma":[0.0002254236,0.0001144838,0.0003366109,0.0001250533,0.0001877502,0.0003979635,0.0002377812,0.0004882612,0.0002901899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002589829,"about_ca_system_score_gemma":0.0002165849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003084066,"about_ca_topic_score_gemma":0.0003950109,"domain_scores_codex":[0.9998567,0.00001930015,0.00002631322,0.0000362294,0.00003869892,0.00002262674],"domain_scores_gemma":[0.9998813,0.00002085172,0.0000329627,0.00001713753,0.00002850862,0.00001920414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005573359,0.00002306321,0.0001620423,0.00006411998,0.000006498525,0.00004173107,0.00002123546,0.00006762919,0.9984431,0.00007721139,0.00004294892,0.0009946807],"study_design_scores_gemma":[0.000006956722,0.0001849564,0.0006849568,0.000005638122,0.00001433763,0.00008160897,0.00001469338,0.0004994649,0.9971611,0.00001322544,0.001329014,0.000003893546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986228,0.001343207,0.01056435,0.0001710751,0.00008886778,0.00008509903,0.000474771,0.0001139812,0.0009306263],"genre_scores_gemma":[0.9900489,0.000814084,0.006137549,0.00008571002,0.00001019423,0.00004606319,0.0008021777,0.00002612069,0.002029277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005819108,"threshold_uncertainty_score":0.001946688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02842562916634259,"score_gpt":0.2510908209106584,"score_spread":0.2226651917443158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}