{"id":"W3174055362","doi":"10.1039/d1ob01062j","title":"Solid-phase synthesis of coralmycin A/<i>epi</i>-coralmycin A and desmethoxycoralmycin A","year":2021,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Burnaby Hospital; Simon Fraser University","funders":"Australian Research Council; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Natural product; Epimer; Acylation; Solid-phase synthesis; Alkylation; Antimicrobial; Stereochemistry; Gram; Residue (chemistry); Antibacterial activity; Total synthesis; Combinatorial chemistry; Organic chemistry; Bacteria; Biochemistry; Peptide; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000794564,0.0003011844,0.0001782618,0.0001601663,0.0001486782,0.0001242739,0.0002142131,0.0001525223,0.002300506],"category_scores_gemma":[0.0000891172,0.0001296344,0.000147324,0.0002236504,0.00008577926,0.0001715874,0.0001931367,0.0003647415,0.001054746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001817649,"about_ca_system_score_gemma":0.0003174688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003853646,"about_ca_topic_score_gemma":0.0007812023,"domain_scores_codex":[0.9999403,0.000009421033,0.000006058662,0.0000125594,0.00001831324,0.00001335279],"domain_scores_gemma":[0.9999517,0.000005117206,0.00001366463,0.000006567314,0.000009052579,0.00001376616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000127743,0.00006468543,0.0000709739,0.0001004365,0.0000055664,0.00009657137,0.0000225439,0.000857519,0.9898633,0.0009327898,0.0002121809,0.007645689],"study_design_scores_gemma":[0.00007317366,0.0008421871,0.0006894796,0.00001234917,0.00001201446,0.0002797683,0.00002411134,0.001689609,0.9741312,0.0003763286,0.02185435,0.0000155289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9290411,0.003491389,0.03730525,0.0001801214,0.0001279854,0.0006422051,0.0033268,0.000451481,0.02543359],"genre_scores_gemma":[0.9652635,0.002062854,0.02398995,0.00008254004,0.00001865554,0.0002350708,0.001521996,0.00005099607,0.00677445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002300506,"threshold_uncertainty_score":0.007695913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009646279333588258,"score_gpt":0.2995725681367426,"score_spread":0.2899262888031544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}