{"id":"W3174064560","doi":"10.1016/j.cell.2021.05.045","title":"Metabolic modeling of single Th17 cells reveals regulators of autoimmunity","year":2021,"lang":"en","type":"article","venue":"Cell","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":501,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Canada First Research Excellence Fund; Australian Academy of Science; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Österreichischen Akademie der Wissenschaften; Chan Zuckerberg Initiative; National Multiple Sclerosis Society","keywords":"Biology; FOXP3; Cell biology; Autoimmunity; Metabolic pathway; Transcriptome; Immune system; Epigenome; Inflammation; Metabolism; Immunology; Biochemistry; Gene expression; Gene; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001763028,0.0001025843,0.0003058675,0.00007768503,0.00006197832,0.00000411228,0.0001098704,0.0001559391,0.00175508],"category_scores_gemma":[0.00004353568,0.0001005987,0.0001467077,0.0001492652,0.00007163261,0.00007500816,0.00006525881,0.0001829904,0.0001423975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001482119,"about_ca_system_score_gemma":0.00004974464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007686158,"about_ca_topic_score_gemma":0.00000182651,"domain_scores_codex":[0.9990729,0.000196969,0.0004013932,0.0001470266,0.00002932208,0.0001523713],"domain_scores_gemma":[0.9991416,0.00005882859,0.0001957398,0.0003698402,0.0002242591,0.000009718528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004268748,0.0002513267,0.0000430484,0.00003588776,0.00005636681,5.243099e-7,0.0003256355,0.0004832004,0.9966958,0.0001607457,0.001608828,0.0002960091],"study_design_scores_gemma":[0.0004287272,0.00005528069,0.0001716814,0.00003167418,0.00005129256,0.000008487902,0.0005673623,0.0001688128,0.9774037,0.00007231743,0.02095594,0.00008473873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9702456,0.008047259,0.0007409841,0.00002405583,0.002494449,0.00006979502,0.000005298625,0.00002805826,0.0183445],"genre_scores_gemma":[0.9750928,0.0001769919,0.0001406009,0.00004663198,0.00001067203,0.000001763457,0.00005647803,0.00001170776,0.02446241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01934711,"threshold_uncertainty_score":0.9991574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01914583731783134,"score_gpt":0.2225926087637006,"score_spread":0.2034467714458692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}