{"id":"W3174064560","doi":"10.1016/j.cell.2021.05.045","title":"Metabolic modeling of single Th17 cells reveals regulators of autoimmunity","year":2021,"lang":"en","type":"article","venue":"Cell","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":501,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Canada First Research Excellence Fund; Australian Academy of Science; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Österreichischen Akademie der Wissenschaften; Chan Zuckerberg Initiative; National Multiple Sclerosis Society","keywords":"Biology; FOXP3; Cell biology; Autoimmunity; Metabolic pathway; Transcriptome; Immune system; Epigenome; Inflammation; Metabolism; Immunology; Biochemistry; Gene expression; Gene; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000158232,0.0003782329,0.0003556148,0.000192141,0.0002005501,0.0006121924,0.0004753916,0.0004344515,0.002006526],"category_scores_gemma":[0.0002600538,0.0001914837,0.0004179163,0.0002452034,0.0002101118,0.0005484761,0.0002284631,0.000305755,0.0002319561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003383149,"about_ca_system_score_gemma":0.0003726853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001540266,"about_ca_topic_score_gemma":0.001491457,"domain_scores_codex":[0.9999462,0.0000141136,0.000001547768,0.00001276398,0.00001007129,0.00001533986],"domain_scores_gemma":[0.9999392,0.00001956155,0.00001186628,0.000009954058,0.000007790329,0.00001164231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002487698,0.00005556467,0.002932131,0.00006679611,0.0000400025,0.0001602111,0.00004554977,0.8873726,0.07680134,0.02460304,0.0002690933,0.007404957],"study_design_scores_gemma":[0.000008839987,0.0000389679,0.0005632167,0.000003062527,0.00001235296,0.00002900688,0.00002301155,0.9843667,0.00812935,0.006168532,0.000650351,0.000006791086],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8645387,0.0006182189,0.1241188,0.0002763304,0.00005309086,0.00001648865,0.0002861008,0.0001049104,0.009987348],"genre_scores_gemma":[0.9915815,0.0003103819,0.006709215,0.00001750572,0.000008055623,0.00001669108,0.00008486275,0.00003439642,0.001237424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002006526,"threshold_uncertainty_score":0.006712496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01914583731783134,"score_gpt":0.2225926087637006,"score_spread":0.2034467714458692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}