{"id":"W3174070807","doi":"10.1056/nejmoa2028631","title":"Daratumumab-Based Treatment for Immunoglobulin Light-Chain Amyloidosis","year":2021,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":668,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; London Health Sciences Centre; Vancouver General Hospital; Western University; University of Alberta","funders":"Janssen Research and Development; European Hematology Association","keywords":"Daratumumab; Medicine; AL amyloidosis; Internal medicine; Amyloidosis; Gastroenterology; Bortezomib; Surgery; Multiple myeloma; Immunology; Immunoglobulin light chain; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007162147,0.0003802485,0.001066248,0.0003228573,0.0002636847,0.0002417947,0.0003029437,0.0003744151,0.001636162],"category_scores_gemma":[0.0009294226,0.0001204749,0.0005399735,0.0002167287,0.0002528751,0.0001436045,0.0001822244,0.0007797371,0.000315748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003472223,"about_ca_system_score_gemma":0.0003507237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002218853,"about_ca_topic_score_gemma":0.0005728413,"domain_scores_codex":[0.9996045,0.0002068601,0.00004496804,0.00004865832,0.00005027391,0.00004472639],"domain_scores_gemma":[0.9996567,0.0001210591,0.00008830195,0.0000203929,0.00001871122,0.00009491348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.277597,0.01179872,0.01985944,0.002674494,0.002535766,0.001385357,0.0002148466,0.003613759,0.03083615,0.001229838,0.006704359,0.6415503],"study_design_scores_gemma":[0.5532711,0.276795,0.1045807,0.0004780211,0.002850772,0.005698872,0.0001043599,0.005640816,0.01020226,0.00206945,0.03822101,0.00008756977],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812182,0.01414287,0.000845531,0.0006282356,0.0002954765,0.0009059672,0.0001633933,0.00005317205,0.001747175],"genre_scores_gemma":[0.9935178,0.003506371,0.001042878,0.0005493393,0.0001540871,0.0004443474,0.0002014189,0.000005205307,0.0005787187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001636162,"threshold_uncertainty_score":0.005473435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01878249456538114,"score_gpt":0.2913909550621601,"score_spread":0.272608460496779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}