{"id":"W3174118295","doi":"10.1002/cpt.2345","title":"The Role of Pharmacogenetics in Smoking","year":2021,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research","keywords":"Genome-wide association study; Nicotine; Varenicline; Candidate gene; Smoking cessation; CYP2A6; Nicotinic agonist; Heritability; Twin study; Pharmacogenetics; Genetic association; Nicotine replacement therapy; Single-nucleotide polymorphism; Medicine; Genetics; Bioinformatics; Biology; Gene; Genotype; Psychiatry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008464854,0.000627099,0.00125605,0.001229831,0.0001933136,0.001027825,0.0006431901,0.001290667,0.003513386],"category_scores_gemma":[0.001336583,0.0001965612,0.0006774883,0.00134956,0.0004925444,0.0007956605,0.0006965977,0.00171575,0.001307939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006062323,"about_ca_system_score_gemma":0.001196932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00158787,"about_ca_topic_score_gemma":0.001780157,"domain_scores_codex":[0.9996829,0.0000921747,0.00003691003,0.00007543885,0.00008966398,0.00002289605],"domain_scores_gemma":[0.9992808,0.0005301015,0.00005163555,0.00001976291,0.00008629327,0.00003153616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005355303,0.00004656124,0.0006533933,0.008176656,0.0001666894,0.000166488,0.00004367367,0.0003359261,0.0005217568,0.006088695,0.01247514,0.9712715],"study_design_scores_gemma":[0.00002018844,0.000103387,0.004271149,0.007215012,0.0003482006,0.001963547,0.00005784011,0.0002281081,0.0003810656,0.008539028,0.9768404,0.00003205018],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000126181,0.9976717,0.0002250128,0.0006684709,0.0001362259,0.000002851503,0.00002371509,0.000007564242,0.001138385],"genre_scores_gemma":[0.001198974,0.9976895,0.0001612797,0.0003186644,0.0002237028,0.000005730752,0.00002839831,0.000001955243,0.0003718085],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003513386,"threshold_uncertainty_score":0.0117535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.206735505387785,"score_gpt":0.5280580195504998,"score_spread":0.3213225141627147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}