{"id":"W3174182354","doi":"10.7554/elife.65150","title":"Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer","year":2021,"lang":"en","type":"article","venue":"eLife","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire en santé mentale de Montréal; Jewish General Hospital; University of Ottawa; McGill University; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Terry Fox Research Institute; Canadian Institutes of Health Research; Fondation du cancer du sein du Québec; Canada Research Chairs; McGill University","keywords":"Doxorubicin; Anthracycline; Biology; Cancer research; Pharmacology; Cancer cell; Epirubicin; Breast cancer; Glutamine; Cancer; Chemotherapy; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000927485,0.0001891115,0.0002781609,0.0001796907,0.0001053601,0.0002727789,0.00008088507,0.0002212537,0.0006737239],"category_scores_gemma":[0.0001153525,0.0001210518,0.0001523041,0.0002309163,0.0001363671,0.0001301762,0.0001710452,0.000306347,0.0001606833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002859601,"about_ca_system_score_gemma":0.0001301497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005837912,"about_ca_topic_score_gemma":0.001375647,"domain_scores_codex":[0.9998981,0.00001140302,0.000007640102,0.00002916587,0.00002621419,0.00002751936],"domain_scores_gemma":[0.9999433,0.000008174676,0.00002066122,0.000007249838,0.000009946183,0.00001084409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009709068,0.000008395204,0.001086338,0.00001939047,0.000005556337,0.00002383493,0.00001305254,0.00008747653,0.9971404,0.00005123927,0.00004195353,0.001425171],"study_design_scores_gemma":[0.00001549344,0.0003781957,0.1140224,0.00001203109,0.00003403556,0.0005529569,0.0001729689,0.001666859,0.8787985,0.0003125073,0.004020344,0.00001369463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994337,0.001520762,0.001870301,0.0002271603,0.0000140241,0.00001448994,0.001007265,0.00006571312,0.000943279],"genre_scores_gemma":[0.994723,0.001456904,0.001289667,0.0001318039,0.000005696993,0.00002841423,0.0009912488,0.00001767151,0.001355697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006737239,"threshold_uncertainty_score":0.002253771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009727451605039013,"score_gpt":0.2625719407230697,"score_spread":0.2528444891180306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}