{"id":"W3174182354","doi":"10.7554/elife.65150","title":"Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer","year":2021,"lang":"en","type":"article","venue":"eLife","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire en santé mentale de Montréal; Jewish General Hospital; University of Ottawa; McGill University; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Terry Fox Research Institute; Canadian Institutes of Health Research; Fondation du cancer du sein du Québec; Canada Research Chairs; McGill University","keywords":"Doxorubicin; Anthracycline; Biology; Cancer research; Pharmacology; Cancer cell; Epirubicin; Breast cancer; Glutamine; Cancer; Chemotherapy; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008908239,0.0001634674,0.0002470679,0.00003782112,0.00006481636,0.00002928822,0.00009315739,0.00008966129,0.00004907482],"category_scores_gemma":[0.00003475156,0.0001542646,0.00005014906,0.0001422797,0.00004100498,0.00000629294,0.0001114727,0.00009373124,0.000002498295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002587389,"about_ca_system_score_gemma":0.0001554105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007345947,"about_ca_topic_score_gemma":0.002719421,"domain_scores_codex":[0.9989422,0.00004014109,0.0001948396,0.0003821558,0.0001827271,0.0002579299],"domain_scores_gemma":[0.9994485,0.00001184488,0.00005038342,0.0002582435,0.0001150752,0.0001158946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002135814,0.0001357005,0.02436194,0.00005297046,0.0000688361,0.000003407638,0.0001043978,0.00002680986,0.9577112,0.00007540701,0.003564516,0.0136812],"study_design_scores_gemma":[0.0005331066,0.000007753898,0.4461243,0.00002539385,0.00002329738,0.00001482225,0.00004320323,0.000005460211,0.2247697,0.0000146401,0.3282728,0.0001655652],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9608782,0.03608273,0.0001882221,0.001646376,0.0005050523,0.0001206049,0.0001323704,0.00001081843,0.0004356017],"genre_scores_gemma":[0.9605772,0.03014322,0.0004262888,0.002868224,0.001369946,0.0000604104,0.0000702543,0.00003041802,0.004454023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7329416,"threshold_uncertainty_score":0.6290727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009727451605039013,"score_gpt":0.2625719407230697,"score_spread":0.2528444891180306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}