{"id":"W3174184405","doi":"10.1039/d1sc02143e","title":"Cellular delivery of dinucleotides by conjugation with small molecules: targeting translation initiation for anticancer applications","year":2021,"lang":"en","type":"article","venue":"Chemical Science","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bureau de Coopération Interuniversitaire","funders":"Narodowe Centrum Badań i Rozwoju; Narodowym Centrum Nauki; Fundacja na rzecz Nauki Polskiej","keywords":"EIF4E; Chemistry; Small molecule; Translation (biology); Computational biology; Ligand (biochemistry); Cell biology; Biochemistry; Biology; Messenger RNA; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001633486,0.0002959492,0.0001842042,0.0001265255,0.000135531,0.0002234255,0.0001403648,0.0003652479,0.0006866552],"category_scores_gemma":[0.0001549518,0.00008044822,0.0001230125,0.0001187755,0.0001560934,0.0001678416,0.0001554643,0.0003045097,0.0001721558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005045771,"about_ca_system_score_gemma":0.0002375132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009647419,"about_ca_topic_score_gemma":0.001811351,"domain_scores_codex":[0.999918,0.00001863996,0.000006272259,0.00001780455,0.0000233375,0.00001588071],"domain_scores_gemma":[0.9999354,0.00001629776,0.00002148959,0.000005713148,0.000008640659,0.00001252123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003540086,0.000009934161,0.00006113005,0.000045469,0.000002647643,0.0000271331,0.000008906708,0.00008913689,0.9974257,0.0001262842,0.00001384624,0.002154392],"study_design_scores_gemma":[0.000004190158,0.00015566,0.0002239532,0.000002421491,0.000005855391,0.00007053745,0.000005264454,0.0002465394,0.9977371,0.00001618055,0.001530254,0.000002132215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807053,0.005060527,0.01153964,0.0001729768,0.00003838688,0.0001178946,0.0001369736,0.00006536269,0.00216294],"genre_scores_gemma":[0.9881025,0.001772628,0.007927235,0.00005264755,0.000009163372,0.0000410059,0.0001156304,0.0000103416,0.001968779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009647419,"threshold_uncertainty_score":0.003661036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0120834642973993,"score_gpt":0.2518675328848536,"score_spread":0.2397840685874543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}