{"id":"W3174184405","doi":"10.1039/d1sc02143e","title":"Cellular delivery of dinucleotides by conjugation with small molecules: targeting translation initiation for anticancer applications","year":2021,"lang":"en","type":"article","venue":"Chemical Science","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bureau de Coopération Interuniversitaire","funders":"Narodowe Centrum Badań i Rozwoju; Narodowym Centrum Nauki; Fundacja na rzecz Nauki Polskiej","keywords":"EIF4E; Chemistry; Small molecule; Translation (biology); Computational biology; Ligand (biochemistry); Cell biology; Biochemistry; Biology; Messenger RNA; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001243654,0.00006436953,0.00007661225,0.00001806047,0.00007146598,0.00001494828,0.00008849661,0.00004772142,7.189323e-7],"category_scores_gemma":[0.00005626184,0.00005073077,0.00003565815,0.0002517715,0.0002676638,0.000008099973,0.0000191991,0.0000273527,1.184044e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001391679,"about_ca_system_score_gemma":0.0000760632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000206827,"about_ca_topic_score_gemma":0.000001748724,"domain_scores_codex":[0.9993548,0.000008396114,0.000136755,0.0002734995,0.0001099881,0.0001165465],"domain_scores_gemma":[0.999413,0.00001721642,0.00008382332,0.0001203338,0.0003296513,0.00003593299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000151207,0.00002715231,0.00009753643,0.00001398935,0.000005226967,8.925752e-8,0.000008787735,0.00001041186,0.994569,0.00005303169,0.00002785465,0.005171769],"study_design_scores_gemma":[0.000123935,0.00003559649,0.00001287918,0.00001258345,0.00001863871,8.9566e-7,0.00004082948,0.0007140304,0.9974005,0.0001268705,0.001429657,0.00008359593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6075886,0.000191619,0.3918523,0.00009608763,0.000005302199,0.0001252772,0.00002146904,0.00001178758,0.0001074933],"genre_scores_gemma":[0.9070798,0.00005262766,0.09248506,0.00006431462,0.0000288955,0.00001868491,0.0002571171,0.000005082584,0.000008493948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2994911,"threshold_uncertainty_score":0.2068741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0120834642973993,"score_gpt":0.2518675328848536,"score_spread":0.2397840685874543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}