{"id":"W3174197955","doi":"10.1096/fasebj.2019.33.1_supplement.503.17","title":"Trans‐synaptic regulation of group III mGluR pharmacology by endogenous allosteric modulators implicated in neuropsychiatric disease","year":2019,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health","keywords":"Allosteric regulation; Endogeny; Neuroscience; Pharmacology; Metabotropic glutamate receptor; Chemistry; Medicine; Glutamate receptor; Biology; Internal medicine; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001287298,0.0002709391,0.0002685486,0.0001057637,0.00009450217,0.0001872539,0.000151493,0.0002119725,0.0006282655],"category_scores_gemma":[0.0001234192,0.00006215645,0.0002323279,0.00008226447,0.0002383928,0.0001087012,0.0001539779,0.0003720268,0.0001195653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002572953,"about_ca_system_score_gemma":0.0001191819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006501628,"about_ca_topic_score_gemma":0.00125581,"domain_scores_codex":[0.9999064,0.00001728412,0.00001101227,0.00001846313,0.00002316624,0.00002376064],"domain_scores_gemma":[0.9999648,0.000005597411,0.0000129848,0.000005271913,0.000004277583,0.0000070367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001679775,0.00002981114,0.001243672,0.00004636788,0.00001248529,0.0002154055,0.00002622318,0.00005719753,0.9949653,0.00009410711,0.00003280934,0.003108761],"study_design_scores_gemma":[0.00004482674,0.001016389,0.0975152,0.0000242811,0.00009342161,0.001803921,0.0001543675,0.001218894,0.8950822,0.0002593375,0.002771977,0.0000150375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995242,0.002057041,0.001536539,0.0001012907,0.00001542264,0.00001885406,0.0001337595,0.00003390912,0.0008612534],"genre_scores_gemma":[0.9977176,0.000937786,0.0008022839,0.00005843169,0.000005683936,0.00001831018,0.00009524654,0.000004301558,0.0003603898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006501628,"threshold_uncertainty_score":0.002101719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008651668048180695,"score_gpt":0.2190646009375055,"score_spread":0.2104129328893248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}