{"id":"W3174261521","doi":"10.1016/j.euroneuro.2021.05.010","title":"Drug development for Autism Spectrum Disorder (ASD): Progress, challenges, and future directions","year":2021,"lang":"en","type":"review","venue":"European Neuropsychopharmacology","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Child Health and Human Development; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Medical Research Council","keywords":"Autism spectrum disorder; Translational research; Intervention (counseling); Optimism; Autism; Extant taxon; Drug development; Psychology; Medicine; Data science; Psychiatry; Computer science; Psychotherapist; Drug","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006639803,0.001132279,0.001856661,0.0006250408,0.000668255,0.0001891997,0.001258609,0.0002225681,0.0002777752],"category_scores_gemma":[0.000106692,0.001054561,0.0004922067,0.0008577346,0.0005294192,0.0001714269,0.0009308349,0.001641265,0.0003299939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001359695,"about_ca_system_score_gemma":0.0004741927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001141206,"about_ca_topic_score_gemma":0.00001309104,"domain_scores_codex":[0.9902785,0.003871182,0.001130867,0.002775031,0.0004906409,0.001453755],"domain_scores_gemma":[0.9973769,0.0007329959,0.0005520593,0.0008527597,0.00001962496,0.0004657001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002785136,0.0004393172,6.177585e-7,0.003639268,0.0001042262,0.0006908334,0.0004519288,1.040926e-7,0.00002127837,0.00932587,0.002400502,0.9828982],"study_design_scores_gemma":[0.00112262,0.0001419712,0.0001498972,0.0006571715,0.000270563,0.0006367634,0.00001656349,0.000004079427,0.000007909085,0.0001495472,0.9959389,0.0009040185],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005359668,0.974599,0.00001044199,0.01228901,0.003978102,0.003356829,0.00007645361,0.0007458417,0.004890704],"genre_scores_gemma":[0.00004681779,0.9938835,0.0002504942,0.0004680378,0.001270043,0.0009043525,0.00005583699,0.0007375526,0.002383376],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9935384,"threshold_uncertainty_score":0.9991904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05650301488203691,"score_gpt":0.3625171581940247,"score_spread":0.3060141433119878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}