{"id":"W3174270804","doi":"10.1158/1535-7163.mct-21-0159","title":"Current Development of Glioblastoma Therapeutic Agents","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"National Cancer Institute","keywords":"Glioblastoma; Tyrosine kinase; Receptor tyrosine kinase; Targeted therapy; Phenotype; Growth factor receptor; Precision medicine; Drug development; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005420584,0.000612799,0.0006660235,0.0009635997,0.0002892811,0.001036927,0.0007636677,0.0009215974,0.005460683],"category_scores_gemma":[0.0004295302,0.0002246452,0.0004896505,0.0005139041,0.0003091799,0.0009988196,0.0006114895,0.001776733,0.003215206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008480884,"about_ca_system_score_gemma":0.000785773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006414225,"about_ca_topic_score_gemma":0.001526191,"domain_scores_codex":[0.9998167,0.00002969929,0.00001915597,0.00003311695,0.00006329882,0.00003806605],"domain_scores_gemma":[0.9998316,0.00002548219,0.00003554227,0.000009278282,0.00006404812,0.00003415785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002595745,0.0002761979,0.0003591307,0.003288692,0.00007033927,0.0002971819,0.0000740804,0.0005099059,0.0259502,0.009396855,0.03378191,0.9257358],"study_design_scores_gemma":[0.0001267083,0.0006591629,0.0008246301,0.0009069681,0.0001088625,0.001140641,0.00004298327,0.0004216237,0.01353247,0.003163087,0.9790494,0.00002339914],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005852201,0.9659864,0.003536547,0.004231365,0.001108363,0.0001170827,0.0003159726,0.0001815061,0.01867064],"genre_scores_gemma":[0.035432,0.9427878,0.004661588,0.004285649,0.0008523283,0.0002557447,0.001224525,0.00003762243,0.01046274],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005460683,"threshold_uncertainty_score":0.01826781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04300872286567232,"score_gpt":0.3326312226341538,"score_spread":0.2896224997684815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}