{"id":"W3174270804","doi":"10.1158/1535-7163.mct-21-0159","title":"Current Development of Glioblastoma Therapeutic Agents","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"National Cancer Institute","keywords":"Glioblastoma; Tyrosine kinase; Receptor tyrosine kinase; Targeted therapy; Phenotype; Growth factor receptor; Precision medicine; Drug development; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005492827,0.0001897815,0.0003050879,0.00007415007,0.00005158353,0.0000129074,0.00007550279,0.00006031324,0.0002349502],"category_scores_gemma":[0.000003168723,0.00016322,0.0001578476,0.0002707478,0.00004109018,0.0000185278,0.00004528831,0.0001071111,0.00001935091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001495325,"about_ca_system_score_gemma":0.0004707865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000417627,"about_ca_topic_score_gemma":0.00001621068,"domain_scores_codex":[0.9987439,0.00004128343,0.0003075342,0.000268607,0.0003900348,0.0002486689],"domain_scores_gemma":[0.9992281,0.00001528049,0.00009429841,0.0003539448,0.0002106497,0.00009773867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000141707,0.001762693,0.02396913,0.000200025,0.001691022,0.0003109639,0.0009224602,0.00004186283,0.3590119,0.0005284386,0.00007267435,0.6113472],"study_design_scores_gemma":[0.001724921,0.0001081443,0.02376719,0.0002045891,0.0004291951,0.00002575383,0.00005837076,0.0001028608,0.8693379,0.000110563,0.1039753,0.0001552791],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.94844,0.04844179,0.001473327,0.0007477367,0.0002976762,0.0002607978,0.000009597573,0.00003264102,0.0002964529],"genre_scores_gemma":[0.9959399,0.001265164,0.001379469,0.001199629,0.00003144887,0.00008780938,0.00001866945,0.00003679492,0.00004112129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6111919,"threshold_uncertainty_score":0.665592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04300872286567232,"score_gpt":0.3326312226341538,"score_spread":0.2896224997684815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}