{"id":"W3174287273","doi":"10.1186/s13395-021-00265-6","title":"Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors—time for new definitions","year":2021,"lang":"en","type":"review","venue":"Skeletal Muscle","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Comisión Nacional de Investigación Científica y Tecnológica; AFM-Téléthon; Fondation pour la Recherche Médicale; Victor Chang Cardiac Research Institute; Michael Smith Health Research BC; European Molecular Biology Organization; Adobe Systems","keywords":"Adipogenesis; Cell biology; Progenitor cell; Biology; Stromal cell; Regeneration (biology); Extracellular matrix; Stem cell; Mesenchymal stem cell; Regenerative medicine; Cellular differentiation; Immunology; Cancer research; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001537547,0.000548508,0.001200126,0.00009758759,0.0001658673,0.00002621453,0.0003331671,0.0006938002,0.00008858027],"category_scores_gemma":[0.0001558181,0.0005289898,0.001173,0.0002044728,0.0002427107,0.00001045,0.0002621473,0.0002163293,0.00002645671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003430354,"about_ca_system_score_gemma":0.0007136063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005528634,"about_ca_topic_score_gemma":0.00003699842,"domain_scores_codex":[0.9976544,0.0001818372,0.0006293948,0.0008928076,0.0001426077,0.0004989658],"domain_scores_gemma":[0.9985572,0.00007792158,0.0003412422,0.0006786276,0.000117068,0.000227967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001419362,0.0002645868,0.000004266255,0.005417934,0.0007249314,0.000004418392,0.00001473608,0.00000235459,0.01084921,0.0008559069,0.002629339,0.9792181],"study_design_scores_gemma":[0.0005334812,0.0004823729,0.0000718382,0.0006168107,0.0006505744,0.00002920752,0.0000102146,0.000002838756,0.0005729714,0.0002637756,0.9961897,0.0005762803],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01162905,0.9859332,0.0001866504,0.00002310668,0.0002592683,0.001011202,0.0006676676,0.00002685707,0.0002629973],"genre_scores_gemma":[0.004515228,0.9890029,0.001397399,0.0000571681,0.0006298372,0.0002397752,0.003761862,0.0001097905,0.0002860542],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9935603,"threshold_uncertainty_score":0.9997162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03165333388363219,"score_gpt":0.3009486179186918,"score_spread":0.2692952840350596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}