{"id":"W3174295420","doi":"10.1016/j.leukres.2021.106650","title":"Human Leucocyte Antigen alleles associated with asparaginase hypersensitivity in childhood Acute Lymphoblastic Leukemia patients treated with Pegylated asparaginase within Dana Farber Cancer Institute treatment protocols","year":2021,"lang":"en","type":"letter","venue":"Leukemia Research","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fondation Charles-Bruneau; Leukemia and Lymphoma Society of Canada; Cancer Research Society","keywords":"Asparaginase; Medicine; Lymphoblastic Leukemia; Immunology; Leukemia; PEGylation; Allele; Human leukocyte antigen; Antigen; PEG ratio; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004892465,0.000215821,0.0004037674,0.000349105,0.0009749053,0.0006161958,0.0003067808,0.00286313,0.002167126],"category_scores_gemma":[0.002884255,0.0002065404,0.0002945766,0.0005801136,0.0004651448,0.0003064058,0.0001866522,0.001879001,0.0003796908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00143249,"about_ca_system_score_gemma":0.001297663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005697611,"about_ca_topic_score_gemma":0.009575064,"domain_scores_codex":[0.9994527,0.0001852176,0.00006134764,0.00005737501,0.0001050192,0.0001384319],"domain_scores_gemma":[0.9986793,0.0006781649,0.0001862198,0.00004134019,0.0001171301,0.0002978177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001812864,0.0005693281,0.6389264,0.0001139935,0.00009054373,0.1489127,0.001010341,0.0007631003,0.006177586,0.004382735,0.1549754,0.04226485],"study_design_scores_gemma":[0.0009686974,0.001923908,0.5590476,0.0003961241,0.0003292257,0.2489286,0.004186985,0.004268474,0.005260655,0.006971021,0.1676189,0.00009981717],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6872216,0.002668846,0.0005240398,0.2630707,0.003454349,0.0001345091,0.0007184502,0.00006370481,0.04214364],"genre_scores_gemma":[0.9171849,0.001573068,0.0005376678,0.07067946,0.003695002,0.00006987515,0.000350148,0.00002943617,0.005880415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005697611,"threshold_uncertainty_score":0.01132888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05192464837148177,"score_gpt":0.3452029344419215,"score_spread":0.2932782860704397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}