{"id":"W3174298791","doi":"10.1103/physreve.105.034411","title":"Promoter methylation in a mixed feedback loop circadian clock model","year":2022,"lang":"en","type":"article","venue":"Physical review. E","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"DNA methylation; Circadian clock; Circadian rhythm; Epigenetics; Methylation; Biology; Promoter; Computer science; Genetics; Computational biology; Gene; Neuroscience; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002638426,0.0001503542,0.0003209455,0.00007210879,0.0001191783,0.00001823199,0.0002336435,0.00001935446,0.0001101101],"category_scores_gemma":[0.000285898,0.0001475711,0.0001516367,0.0006712111,0.00004102084,0.0001532734,0.0001308584,0.0003967939,0.0002775589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001185307,"about_ca_system_score_gemma":0.00007785542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008145001,"about_ca_topic_score_gemma":0.000002845112,"domain_scores_codex":[0.9982868,0.0002914108,0.0002566353,0.0004679749,0.000366185,0.0003309958],"domain_scores_gemma":[0.999324,0.0001128288,0.00009199217,0.000329176,0.00001367937,0.0001283571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00005171081,0.001353056,0.0006015494,0.0009614463,0.00001003155,0.0001178084,0.001924009,0.005849786,0.6354072,0.2580735,0.004002548,0.09164737],"study_design_scores_gemma":[0.002263345,0.0003692996,0.007798268,0.0008516245,0.0001260751,0.0001000468,0.0000529382,0.5021218,0.3053685,0.0616657,0.1176754,0.001607025],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883884,0.003453852,0.0001674324,0.00223806,0.0001564665,0.0008713125,0.00002501718,0.00005972593,0.004639726],"genre_scores_gemma":[0.9957607,0.0007329751,0.00004667717,0.002550163,0.00008140924,0.0002467635,0.000006604939,0.00002540874,0.0005492831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4962721,"threshold_uncertainty_score":0.6017775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04290525498176961,"score_gpt":0.3201633752719962,"score_spread":0.2772581202902266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}