{"id":"W3174336296","doi":"10.1096/fasebj.2018.32.1_supplement.652.7","title":"Calsequestrin, a new modulator of unfolded protein response in skeletal and cardiac muscle","year":2018,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary; University of Alberta","funders":"","keywords":"Calsequestrin; Unfolded protein response; Endoplasmic reticulum; Skeletal muscle; Cell biology; Cardiac muscle; XBP1; Chemistry; Biology; Biochemistry; Endocrinology; Ryanodine receptor; RNA splicing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001066435,0.000310156,0.0002851659,0.0002273239,0.0002312309,0.0002345823,0.0002233143,0.000345052,0.0007019723],"category_scores_gemma":[0.00006361336,0.00008958318,0.0001362561,0.0002216185,0.0002147741,0.0002518964,0.00017504,0.000495041,0.0001653175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002656864,"about_ca_system_score_gemma":0.0001530379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002765178,"about_ca_topic_score_gemma":0.0004637066,"domain_scores_codex":[0.999941,0.00000541172,0.000003026955,0.00002254847,0.0000204168,0.000007687425],"domain_scores_gemma":[0.9999673,0.000003094563,0.000009891294,0.000001423964,0.000006430639,0.00001184359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001352247,0.0000349308,0.0006377414,0.0001986761,0.00001001942,0.0003873387,0.0000359431,0.0001220198,0.9855378,0.0004820463,0.0004541281,0.01196408],"study_design_scores_gemma":[0.0001145756,0.001568016,0.05451834,0.0001277717,0.0001441294,0.004915353,0.0001568008,0.004265958,0.8156377,0.002221722,0.1162862,0.00004354499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7267143,0.2311928,0.02089649,0.001879203,0.0009407031,0.0001357189,0.001277885,0.0005435137,0.01641945],"genre_scores_gemma":[0.9225103,0.05575892,0.008960281,0.0005901748,0.0004771771,0.00008786349,0.001086549,0.0000273088,0.01050145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007019723,"threshold_uncertainty_score":0.002348304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007839113887323675,"score_gpt":0.2413303684601525,"score_spread":0.2334912545728288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}