{"id":"W3174375181","doi":"10.1096/fasebj.27.1_supplement.1040.1","title":"Role of the GRK2 extreme amino terminus and active site tether in forming G protein‐coupled receptor docking site","year":2013,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"G protein-coupled receptor kinase; G protein-coupled receptor; Beta adrenergic receptor kinase; Phosphorylation; Receptor; Protein kinase domain; Agonist; Docking (animal); Kinase; Cell biology; Biochemistry; Biology; Chemistry; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001991227,0.0004252041,0.0002748524,0.0001099171,0.0002660078,0.0002873413,0.0003498001,0.0004509907,0.0008169903],"category_scores_gemma":[0.000179877,0.0001494474,0.0003554834,0.00006551873,0.0004081266,0.0003107752,0.0003010566,0.0005947565,0.0005777337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003733763,"about_ca_system_score_gemma":0.0003326081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004800585,"about_ca_topic_score_gemma":0.0005096386,"domain_scores_codex":[0.9998877,0.00002344775,0.00001247365,0.00002343295,0.00002633698,0.00002651245],"domain_scores_gemma":[0.9997745,0.0000325498,0.0000849448,0.00002115115,0.00001666216,0.00007008485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000401515,0.00003913853,0.0005886753,0.0000248528,0.000006041369,0.0004038892,0.00001753247,0.0003816645,0.9970406,0.0003151978,0.00003209708,0.0007488711],"study_design_scores_gemma":[0.00006978693,0.0002273484,0.007947095,0.00001207414,0.00002100343,0.001605404,0.00004515547,0.004084014,0.9842052,0.0001929219,0.001571551,0.00001849222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964362,0.0002558421,0.002575851,0.00007953726,0.00001759797,0.00001626786,0.00008130402,0.00003106314,0.0005062876],"genre_scores_gemma":[0.9964032,0.0001108623,0.002663741,0.00006372279,0.000005661019,0.0000118977,0.000153782,0.00001463437,0.0005725516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008169903,"threshold_uncertainty_score":0.002733111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009112591334305932,"score_gpt":0.2059166688164134,"score_spread":0.1968040774821074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}