{"id":"W3174397236","doi":"10.2337/dc21-0300","title":"Efficacy and Safety of Dapagliflozin by Baseline Glycemic Status: A Prespecified Analysis From the DAPA-CKD Trial","year":2021,"lang":"en","type":"article","venue":"Diabetes Care","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"LMC Diabetes & Endocrinology (Canada)","funders":"Relypsa; Cytokinetics; Astellas Pharma; Gilead Sciences; Servier; Satellite Healthcare; University of Glasgow; Kidney Research UK; Bristol-Myers Squibb; Akebia Therapeutics; Steno Diabetes Center Copenhagen; Quest Diagnostics; Novo Nordisk; ReCor Medical; Alnylam Pharmaceuticals; Kowa Company; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; GlaxoSmithKline; Defense Acquisition Program Administration; Amgen; Angion; Pfizer; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Dapagliflozin; Kidney disease; Prediabetes; Internal medicine; Renal function; Diabetes mellitus; Hazard ratio; Type 2 diabetes; Glycemic; Adverse effect; Urology; Endocrinology; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005066032,0.001398414,0.002673168,0.0004151604,0.0003624264,0.001530819,0.0005948404,0.001237882,0.003138161],"category_scores_gemma":[0.006256947,0.0003934702,0.005581378,0.0006877745,0.0004601631,0.0008357749,0.0006193494,0.001878133,0.0003053169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004593812,"about_ca_system_score_gemma":0.0006569839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007846536,"about_ca_topic_score_gemma":0.001703859,"domain_scores_codex":[0.9974173,0.001281784,0.000335238,0.0004245809,0.000309031,0.0002321168],"domain_scores_gemma":[0.9963906,0.001520735,0.00110036,0.0004001088,0.0002062202,0.0003818792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8514469,0.001154486,0.0855471,0.001919981,0.02988734,0.0001669031,0.0001158708,0.001546932,0.001630141,0.0002364194,0.002567111,0.02378089],"study_design_scores_gemma":[0.5154249,0.02216562,0.4013472,0.0004930212,0.05078253,0.0004413662,0.0001274577,0.003192549,0.0009516251,0.001501217,0.003436546,0.0001360134],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766149,0.01476944,0.0006861674,0.0004453205,0.0001728838,0.0007108022,0.004331276,0.00004511445,0.002224139],"genre_scores_gemma":[0.9919552,0.001837799,0.0003847265,0.0004273282,0.0001983313,0.0006125016,0.004152419,0.00001355487,0.0004181916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005066032,"threshold_uncertainty_score":0.02679211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01217935964570861,"score_gpt":0.2498091595031481,"score_spread":0.2376297998574394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}