{"id":"W3174398710","doi":"10.1021/acs.jpcb.1c04075","title":"Volumetric Interplay between the Conformational States Adopted by Guanine-Rich DNA from the c-MYC Promoter","year":2021,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry B","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Duplex (building); Phase diagram; G-quadruplex; Chemistry; DNA; Thermodynamics; Hydrostatic pressure; Chemical stability; Crystallography; Biophysics; Phase (matter); Physics; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001438615,0.0001414884,0.0001354973,0.0002435204,0.0001501415,0.0003248822,0.0002062804,0.0001242354,0.0006877423],"category_scores_gemma":[0.0006509151,0.0001490264,0.00009815236,0.0002005692,0.0004922556,0.0003655229,0.0002440983,0.0003326937,0.00006531841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002128985,"about_ca_system_score_gemma":0.0001733738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004489064,"about_ca_topic_score_gemma":0.0006195838,"domain_scores_codex":[0.9999106,0.00001154603,0.000004606748,0.00001874361,0.00003232006,0.00002211886],"domain_scores_gemma":[0.9997467,0.0001135147,0.0000681007,0.0000110239,0.00003017886,0.00003056338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001258072,0.00001899836,0.001946821,0.00004463663,0.000007771536,0.00004574835,0.0001251121,0.000776028,0.9942836,0.0003804629,0.00001439211,0.002230575],"study_design_scores_gemma":[0.00001048796,0.0003191497,0.03490741,0.00001085011,0.00001757169,0.0001832639,0.0002734655,0.01131521,0.9516277,0.0006844153,0.000619268,0.00003116654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986221,0.0001000865,0.0008027623,0.00001234681,0.000001777977,0.00000484709,0.00004070043,0.00001456551,0.000400855],"genre_scores_gemma":[0.9994816,0.00006644236,0.0002487881,0.000007159172,0.000001563599,0.000007757257,0.00008110165,0.00000611855,0.00009952355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006877423,"threshold_uncertainty_score":0.002300739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005161290778422794,"score_gpt":0.2396977766042724,"score_spread":0.2345364858258496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}