{"id":"W3174541599","doi":"10.21203/rs.3.rs-589027/v1","title":"Identification of Essential Protein Domains From High-density Transposon Insertion Sequencing","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Gene; Biology; Genetics; Transposable element; Protein domain; Computational biology; In silico; Transposon mutagenesis; Function (biology); Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000846358,0.0008394971,0.0008001934,0.001343444,0.0004857097,0.0008681526,0.0004599366,0.0007637623,0.00268606],"category_scores_gemma":[0.001855984,0.000372286,0.0009683518,0.0009760369,0.0002997475,0.0004342184,0.0005322483,0.001000854,0.002311458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000568793,"about_ca_system_score_gemma":0.0007695698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001361981,"about_ca_topic_score_gemma":0.002473365,"domain_scores_codex":[0.9995414,0.0000568602,0.00003632084,0.0001516157,0.0001575076,0.0000563274],"domain_scores_gemma":[0.9992531,0.0004069132,0.00009502838,0.00008104191,0.00009794359,0.00006591193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009728128,0.0001941166,0.0260812,0.001882137,0.0002329288,0.001109687,0.0002620381,0.01118045,0.9098751,0.002602014,0.008870398,0.03673711],"study_design_scores_gemma":[0.0002586817,0.0005599917,0.1055233,0.0002550091,0.0004007232,0.001993616,0.0004721611,0.1674905,0.6356329,0.01053864,0.0767123,0.0001621638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6543933,0.002119091,0.2102116,0.0006165445,0.0002481872,0.0003928344,0.1180417,0.00824584,0.00573105],"genre_scores_gemma":[0.5482433,0.001140833,0.2532039,0.0002900859,0.00003866813,0.0002765977,0.1925935,0.001856245,0.002356806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00268606,"threshold_uncertainty_score":0.008985758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04233223852883965,"score_gpt":0.3827935610078383,"score_spread":0.3404613224789986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}