{"id":"W3174556918","doi":"10.1128/spectrum.00339-21","title":"A 28-Day Toxicity Study of Tenofovir Alafenamide Hemifumarate by Subcutaneous Infusion in Rats and Dogs","year":2021,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"Bill and Melinda Gates Foundation","keywords":"Tenofovir alafenamide; Toxicity; Medicine; Tenofovir; Subcutaneous injection; Pharmacology; Internal medicine; Human immunodeficiency virus (HIV); Virology; Viral load; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002942946,0.0002556884,0.0005578219,0.0001507431,0.0001306764,0.00001102913,0.0001754711,0.0002951167,0.000606766],"category_scores_gemma":[0.00006512612,0.0002167894,0.00005821317,0.0002515699,0.0003160225,0.00004228193,0.0002890945,0.0004045906,0.0002458625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008988237,"about_ca_system_score_gemma":0.0001260803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007789145,"about_ca_topic_score_gemma":0.00509666,"domain_scores_codex":[0.9976261,0.0007178774,0.000425956,0.0005824852,0.00002395889,0.0006236364],"domain_scores_gemma":[0.9992263,0.0002197556,0.0001070964,0.000359527,0.00004488929,0.00004243637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003204737,0.001631206,0.06242303,0.00001358579,0.000215119,0.0004706706,0.0007279848,0.000001501166,0.931442,0.00002315044,0.002016517,0.0007148269],"study_design_scores_gemma":[0.005020792,0.002755368,0.01798651,0.00003390609,0.00004405941,0.001297573,0.0007684503,0.000001240198,0.9655108,0.0001328356,0.006142664,0.0003057537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933658,0.004730057,0.000005420763,0.0005985709,0.0001601062,0.0004618776,0.0002629545,0.00003069789,0.0003845548],"genre_scores_gemma":[0.9967466,0.0004133057,0.00001873686,0.00009505766,0.000008371732,0.00002578322,0.000543544,0.0000156711,0.002132947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04443652,"threshold_uncertainty_score":0.8840415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006684153336117153,"score_gpt":0.230779952563269,"score_spread":0.2240957992271518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}