{"id":"W3174556918","doi":"10.1128/spectrum.00339-21","title":"A 28-Day Toxicity Study of Tenofovir Alafenamide Hemifumarate by Subcutaneous Infusion in Rats and Dogs","year":2021,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"Bill and Melinda Gates Foundation","keywords":"Tenofovir alafenamide; Toxicity; Medicine; Tenofovir; Subcutaneous injection; Pharmacology; Internal medicine; Human immunodeficiency virus (HIV); Virology; Viral load; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004149074,0.0006642583,0.0006242962,0.000739108,0.0003633305,0.0003708994,0.0004532719,0.0006425544,0.00125591],"category_scores_gemma":[0.0003314897,0.0002314978,0.0006176417,0.0003439501,0.0007001144,0.0005673186,0.0001585931,0.0009463374,0.0004061415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004787778,"about_ca_system_score_gemma":0.0003571619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001600932,"about_ca_topic_score_gemma":0.001691851,"domain_scores_codex":[0.9997578,0.00004114839,0.00001394769,0.0000583248,0.00005726929,0.00007141668],"domain_scores_gemma":[0.9994937,0.000105511,0.0001465152,0.00007128155,0.00006797142,0.0001150364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008799693,0.006236326,0.005348901,0.0002205328,0.000109646,0.0009507625,0.0003451936,0.002462321,0.9547465,0.0004391481,0.0006830993,0.01965792],"study_design_scores_gemma":[0.0002554042,0.1426211,0.01899601,0.00002703745,0.0002567401,0.00201778,0.0004055979,0.004779041,0.826005,0.0002473183,0.004318741,0.00007023716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965928,0.0009039121,0.001297443,0.00006755306,0.00003955577,0.00005814021,0.0002827458,0.00005491015,0.000702829],"genre_scores_gemma":[0.9935153,0.001581919,0.001294022,0.0000671025,0.00003543825,0.00005391174,0.0005088373,0.00002790396,0.002915677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001600932,"threshold_uncertainty_score":0.004201412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006684153336117153,"score_gpt":0.230779952563269,"score_spread":0.2240957992271518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}