{"id":"W3174557868","doi":"10.1111/hae.14363","title":"The effect of emicizumab prophylaxis on long‐term, self‐reported physical health in persons with haemophilia A without factor VIII inhibitors in the HAVEN 3 and HAVEN 4 studies","year":2021,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Spark Therapeutics; Chugai Pharmaceutical; Genentech; Grifols; Sangamo Therapeutics; Swedish Orphan Biovitrum; CSL Behring; F. Hoffmann-La Roche; Biogen; Novo Nordisk; Sanofi; Alnylam Pharmaceuticals; Pfizer","keywords":"Medicine; Quality of life (healthcare); Haemophilia; Haemophilia A; Pediatrics; Overweight; Internal medicine; Body mass index","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00879605,0.0006530602,0.001740131,0.0008958767,0.000267826,0.0009229497,0.0004117747,0.0005363996,0.001369227],"category_scores_gemma":[0.008742268,0.0004105322,0.005519841,0.000809376,0.0002637508,0.0004440875,0.0006766417,0.0004609751,0.00006858239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004040576,"about_ca_system_score_gemma":0.0003619788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001487536,"about_ca_topic_score_gemma":0.004651322,"domain_scores_codex":[0.9957411,0.0026699,0.0006895188,0.0003721889,0.0004144594,0.0001127326],"domain_scores_gemma":[0.9951998,0.002266487,0.001836739,0.0002877979,0.0002728615,0.0001362642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1006728,0.0003725033,0.4084092,0.02170588,0.3453804,0.0002282141,0.0004698848,0.0007678055,0.002318261,0.0002596416,0.001581147,0.1178343],"study_design_scores_gemma":[0.005994193,0.008051835,0.810646,0.003904179,0.1662085,0.0004608034,0.0002313856,0.0002871354,0.0007009453,0.0001629183,0.003303334,0.00004876934],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6851583,0.3107958,0.0004551456,0.0002614406,0.0001267986,0.0001626741,0.001428696,0.00001221319,0.001599108],"genre_scores_gemma":[0.9846832,0.01396289,0.0003200304,0.0001032981,0.00005260043,0.0001180962,0.0005466365,0.000003557425,0.0002096434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00879605,"threshold_uncertainty_score":0.0465185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03342665425497754,"score_gpt":0.3543646454211475,"score_spread":0.3209379911661699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}