{"id":"W3174557868","doi":"10.1111/hae.14363","title":"The effect of emicizumab prophylaxis on long‐term, self‐reported physical health in persons with haemophilia A without factor VIII inhibitors in the HAVEN 3 and HAVEN 4 studies","year":2021,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Spark Therapeutics; Chugai Pharmaceutical; Genentech; Grifols; Sangamo Therapeutics; Swedish Orphan Biovitrum; CSL Behring; F. Hoffmann-La Roche; Biogen; Novo Nordisk; Sanofi; Alnylam Pharmaceuticals; Pfizer","keywords":"Medicine; Quality of life (healthcare); Haemophilia; Haemophilia A; Pediatrics; Overweight; Internal medicine; Body mass index","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008061551,0.000406966,0.001015733,0.000207383,0.0002660531,0.00004393433,0.0001797861,0.0001188362,0.000005296256],"category_scores_gemma":[0.0003927556,0.0001885319,0.0001528616,0.000742497,0.0005001187,0.00007448415,0.0001138708,0.0007716762,0.000006278286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003127653,"about_ca_system_score_gemma":0.0004223834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008972636,"about_ca_topic_score_gemma":0.0008315786,"domain_scores_codex":[0.9967381,0.0006922128,0.0005075105,0.0006174138,0.0008125063,0.0006322996],"domain_scores_gemma":[0.9979865,0.0007952485,0.0001829528,0.0007307281,0.0001358258,0.0001687661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002612083,0.001256314,0.9383529,0.001222975,0.0008521348,0.002748583,0.02638044,0.000006236508,0.001949723,0.00004123961,0.0004768432,0.02410053],"study_design_scores_gemma":[0.01146823,0.01590908,0.9422569,0.002506375,0.000291817,0.0008052689,0.004425561,0.0002220806,0.02130896,0.0001331361,0.0002123143,0.0004602887],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849409,0.002296674,3.130035e-7,0.01023679,0.00007511017,0.002191576,0.00002314424,0.00003699536,0.0001984778],"genre_scores_gemma":[0.998452,0.0005309865,0.00002648782,0.0001263268,0.0001567871,0.0001713286,0.00002572821,0.00004335822,0.0004670001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02364024,"threshold_uncertainty_score":0.7688109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03342665425497754,"score_gpt":0.3543646454211475,"score_spread":0.3209379911661699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}