{"id":"W3174644994","doi":"10.1371/journal.pgen.1009589","title":"Transcriptomic characterization of cancer-testis antigens identifies MAGEA3 as a driver of tumor progression in hepatocellular carcinoma","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Cancer Institute; Horizon 2020; Generalitat de Catalunya; Asociación Española para el Estudio del Hígado; Cancer Research UK; Foundation for the National Institutes of Health; Fundación Alfonso Martín Escudero; Icahn School of Medicine at Mount Sinai; Samuel Waxman Cancer Research Foundation; Deutsche Forschungsgemeinschaft; EIT Health; National Science Foundation; Damon Runyon Cancer Research Foundation; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; U.S. Department of Defense","keywords":"Biology; Hepatocellular carcinoma; Transcriptome; Cancer research; Liver cancer; Cancer; Carcinoma; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007349172,0.0001356767,0.0003260246,0.000121351,0.0000457052,0.000006973087,0.0001429538,0.0001252646,0.0004605453],"category_scores_gemma":[0.00003094286,0.0001355383,0.00008049366,0.0002094455,0.0001707521,0.0000486866,0.00003797585,0.0001231041,0.00001686278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002017503,"about_ca_system_score_gemma":0.0001982101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005827643,"about_ca_topic_score_gemma":0.00002337257,"domain_scores_codex":[0.9988941,0.0002279195,0.0004246422,0.0001966645,0.00005396284,0.0002027078],"domain_scores_gemma":[0.9993629,0.00003738421,0.0001893688,0.0002487736,0.0001523792,0.000009135392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002364349,0.0002552124,0.175627,0.000117618,0.00008982449,0.00002148549,0.001450919,0.000001501791,0.8208283,0.00001019251,0.000004267087,0.001357195],"study_design_scores_gemma":[0.0007715939,0.0001329769,0.1769141,0.0002108448,0.00004701103,0.00001851538,0.0001179546,0.00006000597,0.8212367,0.00001424388,0.0003717004,0.0001044122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751788,0.02413743,0.00001971894,0.00004233327,0.0002722654,0.0002460402,0.00007002203,0.00001265627,0.00002073697],"genre_scores_gemma":[0.9971511,0.002063283,0.00004550684,0.00002922683,0.000008549904,0.00002229775,0.0001218673,0.00002001234,0.0005381401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02207415,"threshold_uncertainty_score":0.5527089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01520660304422339,"score_gpt":0.2487568208209917,"score_spread":0.2335502177767683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}