{"id":"W3174650925","doi":"10.2139/ssrn.3588570","title":"Directing Therapy with Circulating Tumor DNA Analysis in Advanced Breast Cancer: The PlasmaMATCH Trial","year":2020,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Breast cancer; Medicine; Oncology; Circulating tumor DNA; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006863375,0.0006472557,0.0008984759,0.0001605043,0.0001781479,0.0007040013,0.0003433154,0.0007999029,0.002279036],"category_scores_gemma":[0.0009182452,0.0001427001,0.0005128899,0.0002520077,0.0004524493,0.0006384903,0.0003479404,0.002242411,0.0005774298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005191153,"about_ca_system_score_gemma":0.0004974782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003353386,"about_ca_topic_score_gemma":0.0007787595,"domain_scores_codex":[0.9997887,0.0001115961,0.000006814685,0.00003743441,0.00002138935,0.00003410561],"domain_scores_gemma":[0.9996159,0.0001499638,0.00006052207,0.00003794844,0.00001684389,0.0001188299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4494996,0.007578945,0.01185855,0.0005598387,0.001453406,0.0002903235,0.0002897266,0.003751625,0.02341766,0.001680096,0.008289048,0.4913312],"study_design_scores_gemma":[0.4840552,0.3965251,0.0550625,0.0003152723,0.002101271,0.001766755,0.0004171343,0.005578288,0.01473686,0.008993517,0.03033367,0.0001145239],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849073,0.006454437,0.0009344333,0.002258655,0.0003420909,0.0002708261,0.0004075698,0.00009419153,0.004330495],"genre_scores_gemma":[0.9872386,0.003866923,0.001493174,0.002951872,0.0002506747,0.000394297,0.0006907706,0.00003825926,0.003075382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002279036,"threshold_uncertainty_score":0.007624149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006681773077907887,"score_gpt":0.2362977908320019,"score_spread":0.229616017754094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}