{"id":"W3174745890","doi":"10.1093/hmg/ddab169","title":"Prenatal inflammation as a link between placental expression signature of tryptophan metabolism and preterm birth","year":2021,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Maternal Mental Health During Pregnancy and Postpartum","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada; Agentura Pro Zdravotnický Výzkum České Republiky; Univerzita Karlova v Praze; Institute For Study Abroad Foundation","keywords":"Biology; Fetus; Kynurenine; Placenta; Kynurenine pathway; Pregnancy; Inflammation; Amniotic fluid; Premature rupture of membranes; Physiology; Immunology; Tryptophan; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005804526,0.0001319283,0.0002408905,0.00005484673,0.0000588737,0.0000143403,0.00005506241,0.0001369883,0.00006856858],"category_scores_gemma":[0.00001906528,0.0001283806,0.00005526435,0.00005645688,0.00004377779,0.00003024716,0.00009427801,0.0001766693,0.000003908813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000133255,"about_ca_system_score_gemma":0.00003952035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004660823,"about_ca_topic_score_gemma":9.338868e-7,"domain_scores_codex":[0.9990196,0.00006795629,0.0002897997,0.0002210121,0.0002329119,0.0001687481],"domain_scores_gemma":[0.9994258,0.00001425222,0.0001156245,0.0002390389,0.00005728535,0.0001479873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001814649,0.00005531113,0.01445328,0.00565328,0.00007648243,0.0003007069,0.001226208,0.00000964914,0.9743838,0.0006458077,0.000006473125,0.003007525],"study_design_scores_gemma":[0.001145137,0.0001718002,0.1173087,0.00200517,0.00006130061,0.00006142303,0.00002246202,0.00001611346,0.8780761,0.0006443066,0.0003872203,0.0001003288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990304,0.008577709,0.0001148384,0.0001257393,0.00008189549,0.0003057639,0.00002982696,0.00002089783,0.000439359],"genre_scores_gemma":[0.9976685,0.0002076955,0.00138995,0.00009560948,0.0002028107,0.00001024246,0.0001244661,0.00002285908,0.0002778813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1028554,"threshold_uncertainty_score":0.5235211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01265734507480215,"score_gpt":0.2839026506316902,"score_spread":0.2712453055568881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}