{"id":"W3174825856","doi":"10.1186/s13024-021-00466-z","title":"AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma","year":2021,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Glaucoma and retinal disorders","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Eye Institute; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health","keywords":"AMPK; Neuroscience; Dendrite (mathematics); mTORC1; Protein kinase A; Dendritic spine; Synapse; Biology; AMP-activated protein kinase; Cell biology; Signal transduction; Kinase; Hippocampal formation; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"observational","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001439289,0.0002281651,0.0002549498,0.0003774538,0.0002175137,0.0002289044,0.0001138746,0.0002933801,0.001778607],"category_scores_gemma":[0.0001058057,0.0001203237,0.000227745,0.0001682525,0.0003225567,0.0001515567,0.0002284727,0.0004942045,0.0002297357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002776659,"about_ca_system_score_gemma":0.0001293952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003426575,"about_ca_topic_score_gemma":0.000723448,"domain_scores_codex":[0.9999112,0.0000157621,0.000009288814,0.0000136616,0.00002423209,0.00002582799],"domain_scores_gemma":[0.9999032,0.00001165156,0.00004094805,0.000007385782,0.000005781586,0.00003089545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001379817,0.0001282002,0.003898967,0.00009798277,0.00003098005,0.0006367353,0.00003511112,0.00005868969,0.9901551,0.0001494144,0.0002817299,0.003147353],"study_design_scores_gemma":[0.0003078119,0.003141807,0.3317876,0.000058713,0.0001821344,0.00638815,0.0003314141,0.002242524,0.6512289,0.0005595764,0.003747768,0.00002368006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975469,0.001225485,0.0002579252,0.000101959,0.00003834027,0.00001149229,0.000098087,0.0000269794,0.0006928917],"genre_scores_gemma":[0.9986531,0.000588542,0.0001724004,0.00004650851,0.00001292156,0.00001374361,0.00008767485,0.000004166787,0.000420881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001778607,"threshold_uncertainty_score":0.005950034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007551882914908094,"score_gpt":0.2248714857142412,"score_spread":0.2173196027993331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}