{"id":"W3174874199","doi":"10.1093/nar/gkab561","title":"Pax7 pioneer factor action requires both paired and homeo DNA binding domains","year":2021,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Compute Canada","keywords":"Biology; DNA; Heterochromatin; Binding site; DNA binding site; DNA-binding protein; Enhancer; Transcription factor; Genetics; Chromatin; Cytosine; DNA-binding domain; Molecular biology; Promoter; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003546834,0.0001276473,0.0001324455,0.00008210243,0.000287819,0.0001261341,0.0001672088,0.0002076621,0.0001061407],"category_scores_gemma":[0.0001771922,0.0001261394,0.00005911338,0.0001883306,0.0001456081,0.000008106745,0.0003506282,0.0002186282,0.00002712895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005658516,"about_ca_system_score_gemma":0.0001442923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001401522,"about_ca_topic_score_gemma":0.00005888887,"domain_scores_codex":[0.9985297,0.0001504508,0.0001682814,0.0004246335,0.000310407,0.0004165336],"domain_scores_gemma":[0.9992305,0.00003331756,0.00003714931,0.0003998463,0.0001580998,0.0001410588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002998002,0.00004482218,0.003574875,0.00003774358,0.00004222049,0.00001603771,0.0001248472,0.000002249657,0.9882612,0.0001491798,0.001341214,0.00637559],"study_design_scores_gemma":[0.002113441,0.0008111201,0.0840771,0.00008018877,0.0000246811,0.0001435928,0.00382837,0.001769197,0.7816046,0.001101108,0.1236569,0.0007897314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976395,0.0003458658,0.0001936833,0.0003573282,0.0001127966,0.0001239555,0.00004357751,0.00001550947,0.001167825],"genre_scores_gemma":[0.9949619,0.001118236,0.0008475278,0.00005020735,0.0001956819,0.00001390069,0.0001325355,0.00003646401,0.002643597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2066567,"threshold_uncertainty_score":0.5143816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04788910044120651,"score_gpt":0.327981204893175,"score_spread":0.2800921044519685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}