{"id":"W3174874199","doi":"10.1093/nar/gkab561","title":"Pax7 pioneer factor action requires both paired and homeo DNA binding domains","year":2021,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Compute Canada","keywords":"Biology; DNA; Heterochromatin; Binding site; DNA binding site; DNA-binding protein; Enhancer; Transcription factor; Genetics; Chromatin; Cytosine; DNA-binding domain; Molecular biology; Promoter; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001293094,0.0002474666,0.0002719863,0.0001559101,0.0002031023,0.0003434208,0.0002208777,0.0002606761,0.001910049],"category_scores_gemma":[0.0002113198,0.0002057455,0.0002273323,0.00008044016,0.0003670916,0.000269619,0.0004620399,0.0003914424,0.0005399387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002944306,"about_ca_system_score_gemma":0.0003568958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007416992,"about_ca_topic_score_gemma":0.001568555,"domain_scores_codex":[0.9997867,0.00002139108,0.000009196591,0.00004992365,0.00009406843,0.0000388547],"domain_scores_gemma":[0.9998358,0.00004620952,0.00002484505,0.00002129983,0.00001544254,0.0000563807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002462903,0.00000544935,0.0003097836,0.00001370198,0.000002866052,0.00005479657,0.000009097061,0.0000453282,0.998284,0.0003450924,0.000008447423,0.0008966502],"study_design_scores_gemma":[0.000010087,0.00007445481,0.00881206,0.000005433489,0.000008395705,0.0003891681,0.00004215456,0.001005591,0.9875051,0.0002516668,0.001889799,0.000006071162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883625,0.0007414775,0.008176895,0.00005062881,0.00001193238,0.00001412941,0.00009327262,0.00006335069,0.002485842],"genre_scores_gemma":[0.9938672,0.0002281977,0.003694547,0.00002277562,0.000005205757,0.00001555923,0.000204038,0.00001843483,0.001943956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001910049,"threshold_uncertainty_score":0.006389797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04788910044120651,"score_gpt":0.327981204893175,"score_spread":0.2800921044519685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}