{"id":"W3175084293","doi":"10.1016/j.tips.2021.05.005","title":"Commemorating insulin's centennial: engineering insulin pharmacology towards physiology","year":2021,"lang":"en","type":"review","venue":"Trends in Pharmacological Sciences","topic":"Diabetes Management and Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Insulin; Insulin delivery; Medicine; Insulin receptor; Bioavailability; Pharmacology; Diabetes mellitus; Chemistry; Internal medicine; Endocrinology; Insulin resistance; Type 1 diabetes","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001476389,0.0005571243,0.002403922,0.001098759,0.000173288,0.00007450256,0.0008722638,0.0004114568,0.004500777],"category_scores_gemma":[0.0001998624,0.0003675433,0.0005177776,0.003883223,0.0005850676,0.0001238051,0.000882935,0.001537709,0.00007297184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002447304,"about_ca_system_score_gemma":0.0003114694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001039968,"about_ca_topic_score_gemma":0.000001607536,"domain_scores_codex":[0.9957374,0.0005657952,0.0008797126,0.001060334,0.0005782302,0.001178528],"domain_scores_gemma":[0.998707,0.0004880349,0.0002481189,0.0001826209,0.00007543169,0.0002987793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001770867,0.000541087,0.00001608093,0.001983348,0.0002115111,0.0003689016,0.00002031239,0.00005577186,0.0001733964,0.00009782959,0.004277897,0.9922361],"study_design_scores_gemma":[0.00132898,0.0004566998,0.0002193647,0.001790262,0.0006936767,0.00001741068,0.0000223592,0.002133079,0.00004041348,0.000011041,0.9928561,0.0004306193],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009488806,0.9883077,0.000003429604,0.0008852218,0.0015781,0.0006232141,0.00001750196,0.0001473768,0.007488619],"genre_scores_gemma":[0.001752748,0.99482,0.0006139506,0.0006332552,0.0008611634,0.0002527964,0.0001521141,0.00003170686,0.0008822447],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9918056,"threshold_uncertainty_score":0.9998776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1852281617190956,"score_gpt":0.4762187829936572,"score_spread":0.2909906212745617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}