{"id":"W3175084293","doi":"10.1016/j.tips.2021.05.005","title":"Commemorating insulin's centennial: engineering insulin pharmacology towards physiology","year":2021,"lang":"en","type":"review","venue":"Trends in Pharmacological Sciences","topic":"Diabetes Management and Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Insulin; Insulin delivery; Medicine; Insulin receptor; Bioavailability; Pharmacology; Diabetes mellitus; Chemistry; Internal medicine; Endocrinology; Insulin resistance; Type 1 diabetes","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008279817,0.0007020463,0.0008004756,0.001914712,0.0004231375,0.001694923,0.0006548245,0.0011711,0.002709365],"category_scores_gemma":[0.0007618669,0.0002358997,0.0004120197,0.00209231,0.001047769,0.002927098,0.001009578,0.003606332,0.002435912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008559027,"about_ca_system_score_gemma":0.00107776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006783004,"about_ca_topic_score_gemma":0.001028002,"domain_scores_codex":[0.999737,0.00005411811,0.00003014445,0.00003966334,0.0001120069,0.00002711259],"domain_scores_gemma":[0.9996737,0.0001570028,0.00003081795,0.00001492475,0.00007984768,0.00004362813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008067185,0.00008458869,0.0001633575,0.008927959,0.00004673107,0.0001885361,0.0002147179,0.0002484515,0.003406067,0.0324534,0.05109809,0.9030875],"study_design_scores_gemma":[0.000005525807,0.00005555612,0.0001944766,0.0010421,0.00001400182,0.0003838252,0.00005075955,0.00005290994,0.0005317646,0.004611543,0.9930471,0.0000104463],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001286458,0.994904,0.0004127328,0.00123344,0.001076749,0.000004174461,0.000009620246,0.00001304945,0.00221758],"genre_scores_gemma":[0.0009491866,0.995704,0.0003880088,0.0007467843,0.0005890771,0.000006932169,0.00002031368,0.000005018288,0.001590756],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002709365,"threshold_uncertainty_score":0.009063721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1852281617190956,"score_gpt":0.4762187829936572,"score_spread":0.2909906212745617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}