{"id":"W3175085359","doi":"10.1016/j.pharmthera.2021.107929","title":"Microvascular basis of cognitive impairment in type 1 diabetes","year":2021,"lang":"en","type":"review","venue":"Pharmacology & Therapeutics","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Victoria","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Type 2 diabetes; Neuroscience; Diabetes mellitus; Pathological; Blood flow; Blood–brain barrier; Cognition; Blood vessel; Neovascularization; Medicine; Cognitive decline; Cerebral blood flow; Internal medicine; Endocrinology; Psychology; Angiogenesis; Dementia; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003318096,0.0002930332,0.0008534033,0.0001518137,0.0000293728,0.000006127113,0.0002950915,0.0003151559,0.0001722309],"category_scores_gemma":[0.00003296381,0.0002749748,0.0002665725,0.0004418506,0.0001713746,0.000002742993,0.0002093248,0.0003458626,0.00001710103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004964444,"about_ca_system_score_gemma":0.0005445115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001463149,"about_ca_topic_score_gemma":0.000001586795,"domain_scores_codex":[0.997941,0.0006092383,0.0004402233,0.0005114431,0.0001364949,0.0003616695],"domain_scores_gemma":[0.9990005,0.0001351539,0.0002081682,0.0003013475,0.0003012778,0.00005356875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005892201,0.0005559899,0.00009401905,0.003524301,0.00354891,0.00001560749,0.00007214631,0.00001168123,0.02100663,0.000004702555,0.0006024396,0.9705046],"study_design_scores_gemma":[0.000462971,0.000209021,0.00000687219,0.0007406634,0.001080541,0.000007980711,0.00002231454,0.000002457488,0.06612793,0.000005156819,0.9310941,0.0002399483],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001896326,0.9968572,0.00002631026,0.00006529062,0.0003352497,0.000697604,0.00006479219,0.000005849179,0.00005140152],"genre_scores_gemma":[0.0004517525,0.9976052,0.0001720516,0.000498505,0.000186064,0.000123355,0.0006815562,0.00005819792,0.0002233185],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9702647,"threshold_uncertainty_score":0.9999703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.059773680820891,"score_gpt":0.4155253372956749,"score_spread":0.3557516564747839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}