{"id":"W3175106066","doi":"10.1007/s12640-021-00390-6","title":"Brain Targeting and Toxicological Assessment of the Extracellular Vesicle-Packaged Antioxidant Catalase-SKL Following Intranasal Administration in Mice","year":2021,"lang":"en","type":"article","venue":"Neurotoxicity Research","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Weston Brain Institute","keywords":"Nasal administration; Pharmacology; Extracellular; Oxidative stress; Extracellular vesicle; Catalase; Biology; Biochemistry; Microvesicles","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001842671,0.0001570876,0.0002243052,0.0001540341,0.000423537,0.0001673611,0.0003385159,0.00009682334,0.00005681343],"category_scores_gemma":[0.004421996,0.0001341005,0.00009470898,0.001054998,0.0001917288,0.000237299,0.0002781995,0.0008849947,0.000004051901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005324293,"about_ca_system_score_gemma":0.0003297112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005888801,"about_ca_topic_score_gemma":0.00005349271,"domain_scores_codex":[0.9941136,0.003164523,0.0005378195,0.0006884686,0.001061886,0.000433664],"domain_scores_gemma":[0.9979928,0.001321872,0.0001190343,0.0003460509,0.00009805917,0.0001222493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003202083,0.0002042212,0.001130613,0.00003395947,0.000001284771,0.0003475649,0.00008042612,0.00005775035,0.9922985,0.005560656,0.00008167772,0.0001713307],"study_design_scores_gemma":[0.0005517942,0.0002231104,0.01027238,0.00002682587,0.000002566061,0.00004810301,0.00007788774,0.007125985,0.9810815,0.0002728646,0.0002091432,0.0001078438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934127,0.00001996275,0.0003476215,0.004808563,0.0001990829,0.0008347876,0.00001098888,0.00003538837,0.000330842],"genre_scores_gemma":[0.998704,0.00003532042,0.0002946007,0.0005794134,0.00004318257,0.0000510508,0.000003033714,0.00002049569,0.0002689518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.011217,"threshold_uncertainty_score":0.5468457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08485808687564225,"score_gpt":0.3776090772352784,"score_spread":0.2927509903596361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}