{"id":"W3175180947","doi":"10.1021/acsomega.1c01797","title":"Inhibition of the 3CL Protease and SARS-CoV-2 Replication by Dalcetrapib","year":2021,"lang":"en","type":"article","venue":"ACS Omega","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Université Laval; Université de Montréal; Centre hospitalier universitaire de Québec","funders":"DalCor Pharmaceuticals","keywords":"Protease; Cysteine protease; Chemistry; Cysteine; Viral replication; IC50; Biochemistry; Enzyme; Virology; In vitro; Biology; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002486598,0.0007005382,0.0005787847,0.0002707612,0.0002018121,0.0004070693,0.0003250919,0.000518801,0.007285621],"category_scores_gemma":[0.0002971655,0.0002345612,0.0003174107,0.0002174129,0.0002885674,0.0003859506,0.0001808997,0.001332573,0.001197198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003780847,"about_ca_system_score_gemma":0.001053168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002373479,"about_ca_topic_score_gemma":0.003458945,"domain_scores_codex":[0.9997674,0.00004827583,0.00002066549,0.00002533687,0.00006249633,0.00007601564],"domain_scores_gemma":[0.9999079,0.00002118512,0.00001469994,0.00001037807,0.00001589162,0.00003006479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002708217,0.0007440454,0.00059585,0.0002002374,0.00006054451,0.0001425152,0.00004316984,0.0003766629,0.976792,0.0004901043,0.001447799,0.01639881],"study_design_scores_gemma":[0.0005441459,0.003479095,0.006430172,0.00002700812,0.00004413744,0.0004006849,0.00005007345,0.002489227,0.9770419,0.0001710331,0.009306617,0.00001588416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9538351,0.01751106,0.005663219,0.001554501,0.0008392736,0.0003157985,0.00236813,0.00073056,0.01718236],"genre_scores_gemma":[0.9802997,0.00318369,0.004210121,0.0002074825,0.00007033091,0.0001479399,0.002068371,0.00002948582,0.009782865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007285621,"threshold_uncertainty_score":0.02437282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04147319216864009,"score_gpt":0.3414940005965216,"score_spread":0.3000208084278815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}