{"id":"W3175180947","doi":"10.1021/acsomega.1c01797","title":"Inhibition of the 3CL Protease and SARS-CoV-2 Replication by Dalcetrapib","year":2021,"lang":"en","type":"article","venue":"ACS Omega","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Université Laval; Université de Montréal; Centre hospitalier universitaire de Québec","funders":"DalCor Pharmaceuticals","keywords":"Protease; Cysteine protease; Chemistry; Cysteine; Viral replication; IC50; Biochemistry; Enzyme; Virology; In vitro; Biology; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002545567,0.00008051764,0.0001421812,0.00004872155,0.00006222867,0.00001971284,0.00006675565,0.00006532934,0.000001524403],"category_scores_gemma":[0.0005094351,0.00005953147,0.00004856955,0.0003893036,0.0001079928,0.00007738061,0.00008384552,0.0001726373,0.00001121202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003975641,"about_ca_system_score_gemma":0.0001690335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009754894,"about_ca_topic_score_gemma":0.00001239867,"domain_scores_codex":[0.999021,0.00005843431,0.0001805001,0.0002803909,0.0003101082,0.0001495783],"domain_scores_gemma":[0.9990447,0.00004691949,0.00006247547,0.0006480368,0.0001811168,0.00001680536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000575638,0.0001197226,0.01491825,0.0001145134,0.00001859649,0.00001037633,0.0001430019,7.942218e-9,0.9758046,0.0001891124,0.004211296,0.004413007],"study_design_scores_gemma":[0.0007807956,0.0000616813,0.006000328,0.00007678285,0.00002290291,0.0000371948,0.00006126062,0.00002043784,0.9351739,0.0004473771,0.05726146,0.00005581692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937177,0.0007246201,0.00004193469,0.002505367,0.00002988684,0.0004473313,0.00001412539,0.00002409582,0.002494993],"genre_scores_gemma":[0.983543,0.00001341754,0.00005654735,0.01613435,0.0000510945,0.00005883381,0.00001182236,0.00001322802,0.0001177055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05305017,"threshold_uncertainty_score":0.2427623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04147319216864009,"score_gpt":0.3414940005965216,"score_spread":0.3000208084278815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}