{"id":"W3175186896","doi":"10.3390/cells10071568","title":"Senescence and Aging: Does It Impact Cancer Immunotherapies?","year":2021,"lang":"en","type":"review","venue":"Cells","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Cancer Research Society","keywords":"Senescence; Immune system; Cancer; Cellular senescence; Immunology; Immunosenescence; Biology; Immune checkpoint; Cancer cell; Cancer research; Immunotherapy; Medicine; Cell biology; Genetics; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001837613,0.0005952397,0.002220247,0.0001763084,0.00009510232,0.00008932914,0.0001999666,0.0003212532,0.001597222],"category_scores_gemma":[0.00003511418,0.0003630601,0.0005532933,0.0003934716,0.0001671719,0.00007189299,0.00009159863,0.0005368749,0.00006486283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001952084,"about_ca_system_score_gemma":0.0008924133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003653177,"about_ca_topic_score_gemma":0.00002910271,"domain_scores_codex":[0.9978766,0.0001203057,0.0005410448,0.0006767438,0.000295868,0.0004893795],"domain_scores_gemma":[0.9984488,0.0001860277,0.0002681879,0.0007158923,0.0001120258,0.0002690769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000008182263,0.00006131592,0.0001423555,0.01509121,0.0004310504,0.0002017723,0.0003915706,1.092777e-7,0.0004263365,0.000005269534,0.003369333,0.9798715],"study_design_scores_gemma":[0.0002772583,0.00004198428,0.00006385132,0.02820839,0.0007670216,0.0001701191,0.00009378335,0.000001486247,0.0003217616,0.000002262237,0.9696168,0.0004352831],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001804484,0.9977882,0.00001159222,0.0001995827,0.0007479971,0.0005757235,0.00009363623,0.00006345433,0.0003393479],"genre_scores_gemma":[0.00008945593,0.9881774,0.0001402651,0.0003863607,0.0005263106,0.00004970164,0.0000632934,0.00009722625,0.01046995],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9794362,"threshold_uncertainty_score":0.9998822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04263669213797455,"score_gpt":0.3832430714180427,"score_spread":0.3406063792800682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}