{"id":"W3175231874","doi":"10.1515/nanoph-2021-0220","title":"Porphyrin‐lipid nanovesicles (Porphysomes) are effective photosensitizers for photodynamic therapy","year":2021,"lang":"en","type":"article","venue":"Nanophotonics","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; University of Toronto","keywords":"Photodynamic therapy; Photosensitizer; Photothermal therapy; In vivo; Liposome; Drug delivery; Hematoporphyrin; Cancer research; Medicine; Pharmacology; Chemistry; Materials science; Nanotechnology; Photochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001764696,0.0005025411,0.0006096966,0.0001031072,0.000165359,0.00009320381,0.0002668232,0.0002912885,0.00008724016],"category_scores_gemma":[0.00006295604,0.0005190958,0.000379572,0.000539118,0.00007826946,0.0002069373,0.00004498894,0.0002966842,0.00005832584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004213808,"about_ca_system_score_gemma":0.0001525303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001149475,"about_ca_topic_score_gemma":0.00005578914,"domain_scores_codex":[0.9979503,0.00002672881,0.0004241919,0.000522181,0.0003393838,0.0007372766],"domain_scores_gemma":[0.9984742,0.0002986462,0.0001241744,0.0006718754,0.0002602138,0.0001708459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001391689,0.00007705334,0.00006358883,0.0001631418,0.0002788645,0.00006617115,0.0002231536,0.002517636,0.9878179,0.0001208432,0.0007604361,0.007771972],"study_design_scores_gemma":[0.002794929,0.0001301678,0.0003212454,0.00009416302,0.00004618061,0.00004602149,0.0001813624,0.01469347,0.9333279,0.0008873097,0.0468403,0.0006369932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892819,0.00364527,0.001159845,0.00004118989,0.00232648,0.001478151,0.0003586708,0.0006634743,0.001045036],"genre_scores_gemma":[0.9915063,0.002044482,0.004540347,0.000489666,0.0001665487,0.0005033735,0.0001256552,0.0002810443,0.0003425775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05449011,"threshold_uncertainty_score":0.9997261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006990384402191322,"score_gpt":0.2125841090519114,"score_spread":0.2055937246497201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}