{"id":"W3175262917","doi":"10.3233/jad-210530","title":"Effect of Age on Clinical Trial Outcome in Participants with Probable Alzheimer’s Disease","year":2021,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"University of Toronto; Johns Hopkins University; University of Pennsylvania; Cleveland Clinic; National Institute on Aging; Brown University","keywords":"Deep brain stimulation; Clinical trial; Medicine; Population; Disease; Randomized controlled trial; Rating scale; Alzheimer's disease; Internal medicine; Psychology; Parkinson's disease; Developmental psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06794125,0.0009338169,0.002441696,0.0006154422,0.0006518383,0.001091387,0.000661969,0.001842402,0.003324238],"category_scores_gemma":[0.07759373,0.0004399381,0.004750538,0.0006097204,0.001002702,0.001578139,0.00126273,0.00194742,0.0002612135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006873144,"about_ca_system_score_gemma":0.001142249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002839042,"about_ca_topic_score_gemma":0.0006927605,"domain_scores_codex":[0.9118501,0.07565606,0.006349163,0.003016935,0.002191512,0.0009362046],"domain_scores_gemma":[0.8842834,0.08930766,0.01750149,0.003671943,0.002723788,0.002511622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8769796,0.001036207,0.06344271,0.002827519,0.02084959,0.000086438,0.0003270356,0.0006844088,0.001658157,0.0004957442,0.0007790947,0.03083345],"study_design_scores_gemma":[0.1918886,0.2577235,0.4580257,0.001594853,0.06053809,0.000593127,0.0003532106,0.006564995,0.005061746,0.006387038,0.01104325,0.0002259449],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.951462,0.03436098,0.003883749,0.001915358,0.001110882,0.001903653,0.0007942945,0.0001009379,0.004468102],"genre_scores_gemma":[0.9935207,0.0009744486,0.00254001,0.0004273794,0.0002418674,0.00178187,0.000168898,0.00001646388,0.0003284412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06794125,"threshold_uncertainty_score":0.3593119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1540187742934435,"score_gpt":0.423363411338083,"score_spread":0.2693446370446396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}