{"id":"W3175380606","doi":"10.1101/2021.06.29.450315","title":"Heme-dependent siderophore utilization promotes iron-restricted growth of the <i>Staphylococcus aureus hemB</i> small colony variant","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Siderophore; Staphylococcus aureus; Mutant; Hemin; Microbiology; Bacteria; Heme; Biology; In vivo; Intracellular; Auxotrophy; Biochemistry; Enzyme; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001060629,0.0002900143,0.0002055052,0.0001276098,0.0001004216,0.0002796822,0.0002470232,0.0002703874,0.000992624],"category_scores_gemma":[0.0001699234,0.0001094923,0.0001861175,0.00009388537,0.0001506497,0.0000823388,0.0002580458,0.0005960458,0.0005666108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002334568,"about_ca_system_score_gemma":0.0001593962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001568717,"about_ca_topic_score_gemma":0.001569094,"domain_scores_codex":[0.9998487,0.00002182799,0.000013464,0.00003079032,0.00005901346,0.00002615654],"domain_scores_gemma":[0.9998114,0.00003128993,0.00005866834,0.00002613656,0.00002339856,0.00004919345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002132982,0.00001338346,0.0000679953,0.000007381689,0.00000135661,0.00002642942,0.000005354179,0.00001316137,0.9995302,0.00002684596,0.00004222173,0.0002444332],"study_design_scores_gemma":[0.000009136264,0.000221174,0.006352206,0.000009162406,0.000007022569,0.0003398434,0.00005499247,0.001549042,0.9891919,0.00003847215,0.002217492,0.000009412734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948692,0.0003371574,0.00236457,0.0001419118,0.00002665084,0.00002785451,0.0007971824,0.0001404473,0.001294973],"genre_scores_gemma":[0.9944692,0.0001083141,0.002128018,0.00007684529,0.000005247642,0.00002603695,0.001046189,0.00009366758,0.002046528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001568717,"threshold_uncertainty_score":0.003320694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02123573620305957,"score_gpt":0.2314772454879791,"score_spread":0.2102415092849195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}