{"id":"W3175397536","doi":"","title":"Increased DISC1 expression restores mitochondrial axonal transport and rescues RGC function in glaucoma","year":2021,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Cell biology; Glaucoma; Function (biology); Chemistry; Neuroscience; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002868694,0.0005470956,0.0007550677,0.000843023,0.0004694859,0.0007328448,0.0006848266,0.0009483909,0.002255681],"category_scores_gemma":[0.0002739579,0.0003384255,0.0003829676,0.0003383036,0.0009101518,0.0004078191,0.0004809265,0.001310899,0.0007588476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001379849,"about_ca_system_score_gemma":0.000639993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003240675,"about_ca_topic_score_gemma":0.00355933,"domain_scores_codex":[0.9996904,0.00002877559,0.00005266038,0.00005373451,0.00008620646,0.00008821554],"domain_scores_gemma":[0.9996595,0.00005245036,0.00009693069,0.00004445982,0.0000290057,0.0001176901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002698372,0.00004963678,0.0001847931,0.00009110788,0.00001019173,0.0001661902,0.00004253124,0.0001254221,0.9974281,0.0002639225,0.0002149258,0.001153321],"study_design_scores_gemma":[0.00006246664,0.0001561532,0.004559021,0.00001434548,0.00003359824,0.0003303468,0.0001261279,0.001212376,0.989621,0.00007700011,0.003794254,0.00001326124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904301,0.002261046,0.001795913,0.0008505799,0.0002032184,0.00003839147,0.001786137,0.0003256382,0.002308908],"genre_scores_gemma":[0.9926525,0.0008326625,0.001268595,0.000137667,0.00002305534,0.00003035889,0.0008560814,0.00009880527,0.004100254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003240675,"threshold_uncertainty_score":0.01001155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01874817898581747,"score_gpt":0.290716878212732,"score_spread":0.2719686992269145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}