{"id":"W3175533134","doi":"10.1016/j.bbagen.2021.129951","title":"PepBiotics, novel cathelicidin-inspired antimicrobials to fight pulmonary bacterial infections","year":2021,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - General Subjects","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"ZonMw; Nederlandse Cystic Fibrosis Stichting","keywords":"Cathelicidin; Antimicrobial; Staphylococcus aureus; Antimicrobial peptides; Pseudomonas aeruginosa; Microbiology; Antibiotics; In vivo; Antibiotic resistance; Bacteria; Bacterial cell structure; Chemistry; Antibacterial activity; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001374271,0.0003253477,0.0002063363,0.0001870866,0.00008766837,0.0002454905,0.0001685172,0.0003774185,0.0005265004],"category_scores_gemma":[0.0001131544,0.0000915667,0.0001802123,0.0001279918,0.000170436,0.0002896943,0.0002490501,0.0004794158,0.0002329785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000984099,"about_ca_system_score_gemma":0.00007478744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004647298,"about_ca_topic_score_gemma":0.00007135917,"domain_scores_codex":[0.9999321,0.00001620228,0.000006015099,0.00001509936,0.00001950757,0.00001110835],"domain_scores_gemma":[0.9999553,0.000008315395,0.00001497444,0.000002814391,0.00000760755,0.00001091982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001651177,0.00005141142,0.0002623029,0.0005922765,0.0000153709,0.0002292774,0.0000204412,0.0003238882,0.9699242,0.0004554517,0.0002686272,0.02769165],"study_design_scores_gemma":[0.0001144435,0.002333237,0.002798456,0.0001037873,0.00006848549,0.002258376,0.00003833344,0.001791495,0.9370934,0.000408434,0.0529692,0.00002241179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7433714,0.2225985,0.02313845,0.0007578295,0.0005166583,0.0002332662,0.0007242219,0.0003528033,0.008306956],"genre_scores_gemma":[0.9257047,0.04783078,0.02086657,0.0007970644,0.0001881032,0.0001287881,0.0004306626,0.00003331395,0.004019931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005265004,"threshold_uncertainty_score":0.001761258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01539086475784515,"score_gpt":0.2403527825351489,"score_spread":0.2249619177773037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}