{"id":"W3175591306","doi":"10.1096/fasebj.2018.32.1_supplement.805.21","title":"Muscarinic Acetylcholine Type 1 Receptor Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons: A Phenotype Rescued by Antagonist Treatment","year":2018,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital; University of Manitoba","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Neurite; Cell biology; Muscarinic acetylcholine receptor; Biology; Cytoskeleton; Receptor; Neuroscience; Chemistry; Biochemistry; Cell; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001113196,0.0003899295,0.0003837799,0.0001585323,0.0001672582,0.0002635964,0.0003362398,0.0003441645,0.001304909],"category_scores_gemma":[0.00006439921,0.0001896152,0.0003566004,0.000137378,0.0001709235,0.0001421572,0.0001904551,0.0007130655,0.000527831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003968662,"about_ca_system_score_gemma":0.0004168214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001807422,"about_ca_topic_score_gemma":0.004492501,"domain_scores_codex":[0.9998319,0.00001265848,0.00002535351,0.00003359733,0.00004739059,0.00004894709],"domain_scores_gemma":[0.9998966,0.00001379476,0.0000322309,0.00001088275,0.00001213368,0.00003435735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003161834,0.00001692598,0.00003842639,0.00002405052,0.000002872598,0.00002331437,0.000005908567,0.0000270315,0.9995435,0.00001908623,0.00002095045,0.000246302],"study_design_scores_gemma":[0.000019535,0.0003117652,0.003745916,0.000009556448,0.00001784768,0.0001605602,0.00003072569,0.0004831095,0.9937028,0.00001530761,0.001498205,0.00000466875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952148,0.001009913,0.00138822,0.000110317,0.0000371904,0.00002607179,0.0006028757,0.00009342883,0.001517107],"genre_scores_gemma":[0.9874117,0.001729647,0.003095963,0.0001010847,0.000008842295,0.00006793619,0.0008813936,0.00003398626,0.006669438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001807422,"threshold_uncertainty_score":0.004365325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0104974399884093,"score_gpt":0.2383835906765747,"score_spread":0.2278861506881655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}