{"id":"W3175601579","doi":"10.1002/adhm.202100847","title":"The Delivery Challenge of Genome Editing in Human Epithelia","year":2021,"lang":"en","type":"article","venue":"Advanced Healthcare Materials","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Ikerbasque, Basque Foundation for Science","keywords":"Genome editing; CRISPR; Gene delivery; Translation (biology); Computational biology; Cas9; Computer science; Genetic enhancement; Gene; Biology; Genetics; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001605247,0.0003386233,0.000627726,0.0002901152,0.0005536988,0.001815058,0.0005174732,0.001544757,0.002038709],"category_scores_gemma":[0.001334075,0.0002823919,0.0003907229,0.0001897172,0.001056638,0.001299577,0.001359016,0.00215906,0.001499915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009058854,"about_ca_system_score_gemma":0.001169013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007660617,"about_ca_topic_score_gemma":0.0008036244,"domain_scores_codex":[0.9992173,0.0002685508,0.00003881376,0.0001378897,0.0002503964,0.00008701739],"domain_scores_gemma":[0.9994424,0.0002806348,0.0000752,0.00005240447,0.00009563557,0.0000536423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001356173,0.00005204265,0.0005385983,0.003288825,0.00006718864,0.001601776,0.0006069528,0.00265221,0.710961,0.07920907,0.01666578,0.1842209],"study_design_scores_gemma":[0.00002066473,0.0004808281,0.001168345,0.0008949353,0.00009319804,0.00860184,0.0009335944,0.00434615,0.3192168,0.03361583,0.6305506,0.00007719723],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06752046,0.4872496,0.3448022,0.05796416,0.004593183,0.0002046441,0.0005233752,0.001013495,0.03612895],"genre_scores_gemma":[0.4388289,0.3757152,0.1429229,0.01257092,0.002014541,0.0003150383,0.0006234648,0.0003920822,0.02661694],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002038709,"threshold_uncertainty_score":0.00848943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01172291266480937,"score_gpt":0.3232173990819709,"score_spread":0.3114944864171615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}