{"id":"W3175644419","doi":"10.1096/fasebj.2019.33.1_supplement.457.2","title":"Signaling by the Epidermal Growth Factor Receptor regulates DNA repair","year":2019,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"Canadian Institutes of Health Research","keywords":"DNA repair; DNA damage; Epidermal growth factor receptor; Cisplatin; Signal transduction; Cancer research; Cell biology; Tyrosine kinase; Biology; Epidermal growth factor; PI3K/AKT/mTOR pathway; Receptor; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001075445,0.0002378615,0.0001571372,0.000147799,0.000153451,0.0003603052,0.0001688289,0.0002587297,0.002543923],"category_scores_gemma":[0.0000672093,0.00009666886,0.0001864429,0.0001190163,0.0001493382,0.0002780848,0.0002220058,0.0004232524,0.0006579865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000471102,"about_ca_system_score_gemma":0.0003298485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006862313,"about_ca_topic_score_gemma":0.00102049,"domain_scores_codex":[0.9999088,0.00001230212,0.000005861927,0.00002330501,0.00002671573,0.00002308414],"domain_scores_gemma":[0.9999137,0.000008546871,0.00001722466,0.000009533451,0.00001887495,0.00003208406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001124138,0.00001988244,0.0003769356,0.00008193475,0.000003260726,0.00007850463,0.0000138539,0.00004654631,0.9930412,0.000229955,0.0001641754,0.005831327],"study_design_scores_gemma":[0.00003275512,0.000305782,0.03738848,0.00004286961,0.00002707287,0.0006040692,0.0001079472,0.001288378,0.9422691,0.000374751,0.01754697,0.00001182798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9654337,0.01702799,0.005574559,0.0008810566,0.0001490587,0.00009558498,0.001352747,0.0001716893,0.009313696],"genre_scores_gemma":[0.9789358,0.008551676,0.002301462,0.0001181239,0.00002076889,0.00002839106,0.0007747412,0.00001607089,0.009253062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002543923,"threshold_uncertainty_score":0.008510292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01146487507302586,"score_gpt":0.2309654198525971,"score_spread":0.2195005447795713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}