{"id":"W3175681161","doi":"10.3390/cells10071628","title":"Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Providence Health Care Research Institute; Providence Health Care","funders":"Universitair Medisch Centrum Groningen; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw; Jan Kornelis de Cock Stichting","keywords":"Decorin; Proinflammatory cytokine; CTGF; Extracellular matrix; Idiopathic pulmonary fibrosis; Senescence; Cell biology; Fibroblast; Fibrosis; Myofibroblast; Cancer research; Downregulation and upregulation; Pulmonary fibrosis; Biology; Growth factor; Immunology; Pathology; Internal medicine; Medicine; Proteoglycan; Inflammation; Lung; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002295323,0.0002744199,0.0002250403,0.0001964278,0.0001472757,0.0003234016,0.00008778925,0.0001970593,0.0009660283],"category_scores_gemma":[0.0001969287,0.00008418015,0.000312682,0.00008779018,0.0002352442,0.0002270142,0.0001888907,0.0003424982,0.0003157218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001287246,"about_ca_system_score_gemma":0.0001475706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001664198,"about_ca_topic_score_gemma":0.000233826,"domain_scores_codex":[0.9997693,0.00005499524,0.00002421316,0.0000370115,0.00006396453,0.00005048997],"domain_scores_gemma":[0.9996513,0.00007011485,0.00008000832,0.00005875049,0.00007726518,0.00006262049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001102437,0.00001466753,0.0007678735,0.0000943635,0.000004702627,0.0001257274,0.00002982561,0.00001471777,0.9969321,0.00006161079,0.00002464029,0.001819326],"study_design_scores_gemma":[0.00002766709,0.0008763406,0.08665215,0.00004441347,0.00003314764,0.00127202,0.0001499722,0.0006555539,0.9013689,0.000201193,0.008708773,0.00000990955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784135,0.01490944,0.003006533,0.0001701271,0.00006726992,0.00006138188,0.0003442947,0.00006805613,0.002959353],"genre_scores_gemma":[0.9947867,0.002718691,0.000925518,0.00006377827,0.00002707603,0.00003991352,0.000254534,0.000006236359,0.001177431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009660283,"threshold_uncertainty_score":0.003231704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008531880456720696,"score_gpt":0.2203826459150364,"score_spread":0.2118507654583157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}