{"id":"W3175681161","doi":"10.3390/cells10071628","title":"Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Providence Health Care Research Institute; Providence Health Care","funders":"Universitair Medisch Centrum Groningen; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw; Jan Kornelis de Cock Stichting","keywords":"Decorin; Proinflammatory cytokine; CTGF; Extracellular matrix; Idiopathic pulmonary fibrosis; Senescence; Cell biology; Fibroblast; Fibrosis; Myofibroblast; Cancer research; Downregulation and upregulation; Pulmonary fibrosis; Biology; Growth factor; Immunology; Pathology; Internal medicine; Medicine; Proteoglycan; Inflammation; Lung; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0000476828,0.0001383958,0.0002648454,0.00004951008,0.00004125525,0.00001674686,0.00006043437,0.0001220708,0.001069484],"category_scores_gemma":[0.00001726721,0.0001341981,0.0001707927,0.0001770939,0.00005048429,0.00007518547,0.00006725927,0.000111479,0.00008070934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005560906,"about_ca_system_score_gemma":0.00015489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001087374,"about_ca_topic_score_gemma":0.000001804983,"domain_scores_codex":[0.9988107,0.00005005329,0.000311343,0.0003183087,0.0003290799,0.0001805362],"domain_scores_gemma":[0.9990993,0.00003156601,0.0001099697,0.000403884,0.0002155214,0.0001398181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005139973,0.0001732763,0.001283842,0.0003314754,0.00004996255,0.0001575113,0.0002196712,0.0000123194,0.9960777,0.00005293654,0.00095939,0.000167962],"study_design_scores_gemma":[0.0005384847,0.0004236562,0.01362468,0.0009485672,0.000163006,0.00002105072,0.0001125566,0.002025305,0.981451,0.0001281436,0.000433038,0.0001304941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992887,0.0007888171,0.003433661,0.0003780069,0.0002980305,0.0003465905,0.0001582795,0.00004543408,0.001664141],"genre_scores_gemma":[0.9959914,0.0000309595,0.0009860652,0.000223773,0.0001806991,0.000005333553,0.000216733,0.00002216484,0.002342853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01462664,"threshold_uncertainty_score":0.9998437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008531880456720696,"score_gpt":0.2203826459150364,"score_spread":0.2118507654583157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}