{"id":"W3175697174","doi":"10.3390/pathogens10070795","title":"Modern Development and Production of a New Live Attenuated Bacterial Vaccine, SCHU S4 ΔclpB, to Prevent Tularemia","year":2021,"lang":"en","type":"article","venue":"Pathogens","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"Defense Threat Reduction Agency","keywords":"Attenuated vaccine; Francisella tularensis; CLPB; Virulence; Virology; Vaccination; Tularemia; Biology; Biodefense; Pasteurellosis; Microbiology; Immunology; Medicine; Mutant; Genetics; Gene; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001630966,0.0001206958,0.0001582745,0.00002992835,0.0000526171,0.00002033582,0.00007718014,0.0001005588,0.00006678711],"category_scores_gemma":[0.0001991646,0.0001172228,0.0000404192,0.0001031445,0.0000124958,0.000003254195,0.0001784859,0.00005205947,0.00001108521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001754747,"about_ca_system_score_gemma":0.0003235494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001467324,"about_ca_topic_score_gemma":0.0001244075,"domain_scores_codex":[0.9989961,0.0000523406,0.0002099336,0.0003923345,0.0001350029,0.0002142313],"domain_scores_gemma":[0.9993168,0.000003847094,0.0000465423,0.0002532071,0.0002223075,0.0001572677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000170009,0.00007110857,0.0004572161,0.00003181662,0.00004538525,0.000005763972,0.0004245296,0.00001035253,0.9545119,0.000003751141,0.0006344452,0.04363373],"study_design_scores_gemma":[0.0003494602,0.0001191394,0.008153132,0.00002868393,0.00001403361,0.00002083212,0.00004519878,0.00001382501,0.9610262,0.00002487224,0.03005655,0.0001480894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979599,0.0005251147,0.0006896311,0.0002220135,0.0002460078,0.0002361109,0.00002554136,0.000006043269,0.00008963641],"genre_scores_gemma":[0.9926363,0.0001970991,0.004664124,0.00004445915,0.0003894615,0.00001971086,0.0002045015,0.00002079904,0.001823505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04348564,"threshold_uncertainty_score":0.4780208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01632364907250725,"score_gpt":0.2543919152352745,"score_spread":0.2380682661627672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}