{"id":"W3175697174","doi":"10.3390/pathogens10070795","title":"Modern Development and Production of a New Live Attenuated Bacterial Vaccine, SCHU S4 ΔclpB, to Prevent Tularemia","year":2021,"lang":"en","type":"article","venue":"Pathogens","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"Defense Threat Reduction Agency","keywords":"Attenuated vaccine; Francisella tularensis; CLPB; Virulence; Virology; Vaccination; Tularemia; Biology; Biodefense; Pasteurellosis; Microbiology; Immunology; Medicine; Mutant; Genetics; Gene; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004206658,0.0005613733,0.0002602371,0.0005915713,0.0002278594,0.0003705674,0.000470468,0.0005198598,0.0007557098],"category_scores_gemma":[0.0002309923,0.0002151204,0.0004618655,0.0002493488,0.0003930385,0.0003877888,0.0004009804,0.0007071064,0.0004355969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004733464,"about_ca_system_score_gemma":0.0007204417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001042179,"about_ca_topic_score_gemma":0.001077567,"domain_scores_codex":[0.9996898,0.00004489453,0.00002595601,0.00005847912,0.0001410497,0.00003977067],"domain_scores_gemma":[0.9998776,0.00001103123,0.00003592902,0.00001719388,0.0000342876,0.00002403789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004638659,0.0000784755,0.0003149208,0.00009062984,0.00000739912,0.00004338762,0.00002095984,0.0004133213,0.9880551,0.0004152054,0.0001106586,0.01040359],"study_design_scores_gemma":[0.0000273053,0.001508252,0.001887838,0.00002685886,0.00004166147,0.0002886779,0.00002348234,0.001714692,0.9804497,0.0001499053,0.01386715,0.00001439835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9312338,0.008600093,0.05296248,0.0006448507,0.0001979149,0.0004081965,0.0006510753,0.0002812862,0.00502025],"genre_scores_gemma":[0.9201853,0.008142808,0.06238365,0.0002901637,0.00006544116,0.0002452625,0.002424646,0.0000463296,0.006216403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001042179,"threshold_uncertainty_score":0.00343442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01632364907250725,"score_gpt":0.2543919152352745,"score_spread":0.2380682661627672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}