{"id":"W3175732802","doi":"10.1016/j.amjmed.2021.02.022","title":"Concerning Pathophysiology and Justifying Clinical Trials","year":2021,"lang":"en","type":"letter","venue":"The American Journal of Medicine","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"","keywords":"Hydroxychloroquine; Medicine; Azithromycin; Disease; Clinical trial; Population; Coronavirus disease 2019 (COVID-19); Scopus; MEDLINE; Intensive care medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1098597,0.001834194,0.006446086,0.003909962,0.00959282,0.01999455,0.008532156,0.2370302,0.01363286],"category_scores_gemma":[0.3548428,0.002710678,0.00439291,0.003789338,0.0314096,0.01609877,0.008113223,0.1280832,0.01087142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01144927,"about_ca_system_score_gemma":0.02928198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005065564,"about_ca_topic_score_gemma":0.01020023,"domain_scores_codex":[0.8783438,0.06432429,0.01594918,0.01026033,0.0252529,0.005869668],"domain_scores_gemma":[0.5232065,0.3852306,0.0213514,0.01257281,0.0305844,0.02705425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003597233,0.0000809058,0.001095191,0.0003533914,0.0001878834,0.001671851,0.0002888126,0.0001553875,0.0002224646,0.06327444,0.9172946,0.01501546],"study_design_scores_gemma":[0.001175249,0.0001894261,0.0009908306,0.002705047,0.0003175604,0.001546177,0.000488027,0.0007738765,0.0002949213,0.1773384,0.8139613,0.0002191799],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0001230799,0.002596521,0.0001680767,0.9818611,0.01249249,0.00001602858,0.00003069791,0.00001081564,0.002701167],"genre_scores_gemma":[0.001989671,0.001184218,0.0004026442,0.9405587,0.05456649,0.00005317649,0.00002329582,0.00001592135,0.001205846],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2370302,"threshold_uncertainty_score":0.5810004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3411992297560826,"score_gpt":0.565232549020374,"score_spread":0.2240333192642914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}