{"id":"W3175732923","doi":"10.1096/fasebj.26.1_supplement.1088.8","title":"Microglia attenuate the opioid‐induced depression of preBötzinger Complex (preBötC) inspiratory rhythm in vitro via a TLR4‐independent pathway","year":2012,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Neuroscience of respiration and sleep","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute on Drug Abuse; National Institute on Alcohol Abuse and Alcoholism; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions; Women and Children's Health Research Institute","keywords":"DAMGO; Opioid; Agonist; (+)-Naloxone; TLR4; Medicine; Microglia; Anesthesia; Internal medicine; Pharmacology; Chemistry; Enkephalin; Endocrinology; Receptor; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002439012,0.0004380224,0.0003696132,0.0001483448,0.0001611023,0.0001923439,0.0002099153,0.0002838284,0.001828735],"category_scores_gemma":[0.0002121775,0.0001755901,0.0003496211,0.000069786,0.0001853236,0.0001854366,0.0002780394,0.0008504685,0.0004178781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001912538,"about_ca_system_score_gemma":0.0002763238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007634523,"about_ca_topic_score_gemma":0.00144076,"domain_scores_codex":[0.9998362,0.00002897574,0.00001608977,0.00001879116,0.00003452626,0.0000653139],"domain_scores_gemma":[0.9998697,0.00002080304,0.00003522306,0.00001593035,0.00001871086,0.00003956701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007342049,0.00009276861,0.00009624676,0.0000529517,0.000005803022,0.00003710413,0.00002991572,0.000027305,0.9977701,0.00003118893,0.00004168704,0.001080774],"study_design_scores_gemma":[0.00009945824,0.002805703,0.00848988,0.00002289427,0.00003867805,0.0001152816,0.00009655299,0.0007710024,0.9864043,0.00005418157,0.001096719,0.000005333691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957308,0.001535594,0.00104938,0.0001347397,0.00006298348,0.00004278314,0.0002193845,0.00004332107,0.001180993],"genre_scores_gemma":[0.9943844,0.001162103,0.001268467,0.0001139202,0.00003876672,0.0001272464,0.0003007495,0.00001186959,0.002592417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001828735,"threshold_uncertainty_score":0.006117702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05682352643289219,"score_gpt":0.2788089274405769,"score_spread":0.2219854010076848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}