{"id":"W3175747586","doi":"10.4049/jimmunol.2100421","title":"Cutting Edge: Nucleocapsid Vaccine Elicits Spike-Independent SARS-CoV-2 Protective Immunity","year":2021,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; University of Minnesota; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Government of Canada","keywords":"Spike (software development); Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); Immunity; Spike Protein; 2019-20 coronavirus outbreak; Biology; Medicine; Immunology; Immune system; Computer science; Infectious disease (medical specialty); Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002219977,0.0003782813,0.000290344,0.0001523177,0.00009308022,0.000285111,0.0001445985,0.0004777193,0.002185522],"category_scores_gemma":[0.0002130061,0.00008164699,0.0002008576,0.00005684316,0.0001655757,0.0002402957,0.0001923946,0.0006951898,0.0005310038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002018144,"about_ca_system_score_gemma":0.0002020106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009183324,"about_ca_topic_score_gemma":0.0001902903,"domain_scores_codex":[0.9998554,0.00002218471,0.00001179189,0.00002776611,0.00003719746,0.00004567654],"domain_scores_gemma":[0.9998999,0.00002843291,0.00001627226,0.00001417959,0.00001555299,0.0000256652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004088119,0.000191671,0.00035114,0.0001437144,0.000008658551,0.00006323785,0.00001946284,0.0001206311,0.9904881,0.0002543161,0.0003110006,0.007639328],"study_design_scores_gemma":[0.0001801336,0.004954871,0.007743711,0.00005243698,0.00003825732,0.000716172,0.00004820137,0.001776266,0.9775298,0.0003824319,0.006570022,0.000007787701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892893,0.001792415,0.003001218,0.0004691292,0.0002260643,0.00008338479,0.0003158006,0.0001208961,0.004701694],"genre_scores_gemma":[0.9940869,0.0006065072,0.001781541,0.0003430287,0.00007117845,0.0000211148,0.0004166098,0.00001518661,0.002657882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002185522,"threshold_uncertainty_score":0.007311285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03915850643159725,"score_gpt":0.3449155035547778,"score_spread":0.3057569971231806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}