{"id":"W3175752907","doi":"10.1038/s41598-021-93311-8","title":"Membrane vesicles of Lacticaseibacillus rhamnosus JB-1 contain immunomodulatory lipoteichoic acid and are endocytosed by intestinal epithelial cells","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton","funders":"Natural Sciences and Engineering Research Council of Canada; Hospital for Sick Children; McMaster University","keywords":"Lipoteichoic acid; Lactobacillus rhamnosus; Endocytosis; Internalization; Cell biology; TLR2; Bacteria; Biology; Microbiology; Intracellular; Receptor; Chemistry; Lactobacillus; Biochemistry; TLR4; Signal transduction; Staphylococcus aureus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000562869,0.0001764335,0.000363895,0.0001014487,0.0003164469,0.00009535674,0.00007812478,0.000143612,0.0006289594],"category_scores_gemma":[0.0002931876,0.0001600772,0.00009814421,0.0002381003,0.0004197934,0.0001429338,0.0001151339,0.0001810687,0.00003408459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002794936,"about_ca_system_score_gemma":0.0001573165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001216537,"about_ca_topic_score_gemma":0.00004581853,"domain_scores_codex":[0.9983637,0.0001737447,0.0005514503,0.0005740007,0.00004415221,0.0002928977],"domain_scores_gemma":[0.9985954,0.00009940416,0.0004111016,0.0005631857,0.000287456,0.00004349854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005984425,0.0001260807,0.001220515,0.00003316786,0.00007603088,0.0001289056,0.000101841,0.000001221396,0.9936008,0.0000451679,0.002792941,0.001813464],"study_design_scores_gemma":[0.0005494084,0.00007004513,0.001586299,0.00003445487,0.00004833639,0.002135968,0.0001840054,0.000001364431,0.9318427,0.0002071634,0.06318688,0.0001533708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988237,0.002594264,0.00004406037,0.00008880525,0.008613613,0.0001514663,0.0000450796,0.00004749605,0.0001781693],"genre_scores_gemma":[0.9970323,0.00003342133,0.00007007064,0.00001474767,0.00004744908,0.000009614188,0.000137997,0.00001343675,0.002640926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06175811,"threshold_uncertainty_score":0.6886664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015916287527972,"score_gpt":0.224563942601718,"score_spread":0.2144047797264383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}