{"id":"W3175752907","doi":"10.1038/s41598-021-93311-8","title":"Membrane vesicles of Lacticaseibacillus rhamnosus JB-1 contain immunomodulatory lipoteichoic acid and are endocytosed by intestinal epithelial cells","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton","funders":"Natural Sciences and Engineering Research Council of Canada; Hospital for Sick Children; McMaster University","keywords":"Lipoteichoic acid; Lactobacillus rhamnosus; Endocytosis; Internalization; Cell biology; TLR2; Bacteria; Biology; Microbiology; Intracellular; Receptor; Chemistry; Lactobacillus; Biochemistry; TLR4; Signal transduction; Staphylococcus aureus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000128467,0.0002797639,0.0001844088,0.0001703371,0.0001748995,0.0003300158,0.0001201262,0.0002745934,0.0007625794],"category_scores_gemma":[0.0001571128,0.0001043274,0.0002856367,0.00008253541,0.0001487392,0.0002914587,0.0002752594,0.0003276718,0.0004228417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003109939,"about_ca_system_score_gemma":0.0001895236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007364749,"about_ca_topic_score_gemma":0.0005743647,"domain_scores_codex":[0.9999111,0.00001503984,0.000007401578,0.00001670443,0.00002400395,0.00002582306],"domain_scores_gemma":[0.9999243,0.00001263036,0.00002794826,0.000007482827,0.00001084914,0.00001678461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000673937,0.000005657315,0.0002917587,0.00002385797,0.00000319122,0.00003013208,0.00001101169,0.00002461199,0.9989253,0.00005661452,0.000008595269,0.0005518559],"study_design_scores_gemma":[0.000007494118,0.0001485348,0.01124517,0.00001349065,0.00001902573,0.0003859931,0.00007517279,0.0004976486,0.9852183,0.0001003064,0.002282398,0.000006459958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928522,0.002656936,0.002620672,0.0001550845,0.00002426345,0.00001641519,0.0002880951,0.00003223014,0.001354133],"genre_scores_gemma":[0.9944293,0.0009451514,0.001869937,0.0000521845,0.000007249942,0.00001025839,0.0006356664,0.00001928609,0.002030989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007625794,"threshold_uncertainty_score":0.002551079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015916287527972,"score_gpt":0.224563942601718,"score_spread":0.2144047797264383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}